Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

The genome of an invasive skin-tropic strain (AP53) of serotype M53 group A Streptococcus pyogenes (GAS) is composed of a circular chromosome of 1,860,554 bp and carries genetic markers for infection at skin locales, viz, emm gene family pattern D and FCT type 3. Through genome-scale comparisons of...

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Veröffentlicht in:	Journal of bacteriology 2016-06, Vol.198 (12), p.1712-1724
Hauptverfasser:	Bao, Yun-Juan, Liang, Zhong, Mayfield, Jeffrey A, Donahue, Deborah L, Carothers, Katelyn E, Lee, Shaun W, Ploplis, Victoria A, Castellino, Francis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Chromosomes Gene Expression Regulation, Bacterial Genome, Bacterial Genomes Genomics Gram-positive bacteria Humans Mice Mice, Inbred C57BL Mutation Peptides Polymorphism Skin Diseases - microbiology Spotlight Streptococcal Infections - microbiology Streptococcus pyogenes Streptococcus pyogenes - genetics Streptococcus pyogenes - metabolism Streptococcus pyogenes - pathogenicity Virulence Virulence Factors - genetics Virulence Factors - metabolism
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