CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study

BACKGROUND Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synthesizing enzyme 17α-hydroxylase (CYP17A1) to blood pressure (BP). We hypothesized that the genetic signal may translate into a correlation of ambulatory BP (ABP) with apparent CYP17A1 activity in a fami...

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Veröffentlicht in:	American journal of hypertension 2016-04, Vol.29 (4), p.484-493
Hauptverfasser:	Ackermann, Daniel, Pruijm, Menno, Ponte, Belen, Guessous, Idris, Ehret, Georg, Escher, Geneviève, Dick, Bernhard, Al-Alwan, Heba, Vuistiner, Philippe, Paccaud, Fred, Burnier, Michel, Péchère-Bertschi, Antoinette, Martin, Pierre-Yves, Vogt, Bruno, Mohaupt, Markus, Bochud, Murielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Biomarkers - urine Blood Pressure - genetics Blood Pressure Monitoring, Ambulatory Circadian Rhythm Cross-Sectional Studies Epidemiology Female Gene-Environment Interaction Genetic Association Studies Genotype Heredity Humans Hypertension - diagnosis Hypertension - enzymology Hypertension - genetics Hypertension - physiopathology Male Middle Aged Natriuresis Original Phenotype Risk Factors Sodium - urine Sodium Chloride, Dietary - adverse effects Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Steroids - urine Substrate Specificity Switzerland Time Factors Urinalysis Young Adult
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