The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Th1 immune response in mice

Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and evaluated their immunogenicity in BALB/c mice. Our data suggest that the booster vaccin...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2016-04, Vol.48 (4), p.385-390
Hauptverfasser:	Gu, Dongqing, Chen, Wei, Mi, Youjun, Gong, Xueli, Luo, Tao, Bao, Lang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - blood BCG Vaccine - administration & dosage BCG Vaccine - immunology Female Mice Mice, Inbred BALB C Mycobacterium bovis - immunology Original Th1 Cells - classification Th1 Cells - immunology Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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