NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer

The identification and clinical validation of cancer driver genes are essential to accelerate the translational transition of cancer genomics, as well as to find clinically confident targets for the therapeutic intervention of cancers. Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions i...

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Veröffentlicht in:	Oncotarget 2016-02, Vol.7 (7), p.8399-8412
Hauptverfasser:	Park, Do Youn, Choi, Chan, Shin, Eunji, Lee, Jae Hyuk, Kwon, Chae Hwa, Jo, Hong-Jae, Kim, Hyeong-Rok, Kim, Hyun Sung, Oh, Nahmgun, Lee, Ji Shin, Park, Ok Ku, Park, Eok, Park, Jonghoon, Shin, Jong-Yeon, Kim, Jong-Il, Seo, Jeong-Sun, Park, Hee Dong, Park, Joonghoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Carbazoles - pharmacology Carcinogenesis Case-Control Studies Clinical Research Paper Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology Female Follow-Up Studies Gene Fusion High-Throughput Nucleotide Sequencing Humans Immunoenzyme Techniques In Situ Hybridization, Fluorescence Lamin Type A - genetics Lamin Type A - metabolism Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Staging Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Prognosis Protein Kinase Inhibitors - pharmacology Pyrazoles - pharmacology Pyridines - pharmacology Real-Time Polymerase Chain Reaction Receptor, trkA - genetics Receptor, trkA - metabolism Republic of Korea Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate Tropomyosin - genetics Tropomyosin - metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays
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