DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity

Cellular RNA-binding proteins incorporated into virions during human immunodeficiency virus type 1 (HIV-1) assembly promote the replication efficiency of progeny virions. Despite its critical role in bolstering virion infectivity, the molecular basis for the incorporation of DHX9/RNA helicase A (RHA...

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Veröffentlicht in:	Journal of molecular biology 2016-06, Vol.428 (11), p.2418-2429
Hauptverfasser:	Boeras, Ioana, Song, Zhenwei, Moran, Andrew, Franklin, Jarryd, Brown, William Clay, Johnson, Marc, Boris-Lawrie, Kathleen, Heng, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Binding Sites - genetics DEAD-box RNA Helicases - metabolism dimeric 5′-UTR DNA Primers - genetics Genomics HIV Infections - genetics HIV Infections - virology HIV-1 - genetics Human immunodeficiency virus 1 Humans Lentivirus Neoplasm Proteins - metabolism NMR PBS-segment RNA, Viral - genetics RNA-binding domain Virion - genetics Virus Assembly - genetics virus infectivity Virus Replication - genetics
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