The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome

During translation, the two eukaryotic ribosomal subunits remain associated through 17 intersubunit bridges, five of which are eukaryote specific. These are mainly localized to the peripheral regions and are believed to stabilize the structure of the ribosome. The functional importance of these brid...

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Veröffentlicht in:	Journal of molecular biology 2016-05, Vol.428 (10), p.2203-2216
Hauptverfasser:	Kisly, Ivan, Gulay, Suna P., Mäeorg, Uno, Dinman, Jonathan D., Remme, Jaanus, Tamm, Tiina
Format:	Artikel
Sprache:	eng
Schlagworte:	eukaryote-specific bridges Eukaryotic Cells - physiology Mutation - genetics Nucleic Acid Conformation Protein Biosynthesis - genetics Protein Biosynthesis - physiology Ribosomal Proteins - genetics ribosome assembly ribosome subunit association Ribosome Subunits - genetics Ribosome Subunits - physiology RNA, Ribosomal - genetics RNA, Transfer - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - physiology stress tolerance
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