The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila

Ninein (Nin) is a centrosomal protein whose gene is mutated in Seckel syndrome (SCKL, MIM 210600), an inherited recessive disease that results in primordial dwarfism, cognitive deficiencies, and increased sensitivity to genotoxic stress. Nin regulates neural stem cell self-renewal, interkinetic nucl...

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Veröffentlicht in:	Molecular biology of the cell 2016-06, Vol.27 (11), p.1740-1752
Hauptverfasser:	Zheng, Yiming, Mennella, Vito, Marks, Steven, Wildonger, Jill, Elnagdi, Esraa, Agard, David, Megraw, Timothy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Centrioles - metabolism Centrosome - metabolism Centrosome - physiology Cytoskeletal Proteins - metabolism DNA Damage Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Microtubule-Organizing Center - metabolism Microtubules - metabolism Nuclear Proteins - metabolism Stem Cells - metabolism
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