Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro
Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in “eighteen antagonistic medicaments” that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the est...
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| Veröffentlicht in: | Scientific reports 2016-05, Vol.6 (1), p.26924-26924, Article 26924 |
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| creator | Xu, Ying Ding, Jie An, Jin-na Qu, Ya-kun Li, Xin Ma, Xiao-ping Zhang, Yi-min Dai, Guo-jing Lin, Na |
| description | Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in “eighteen antagonistic medicaments” that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect of GS described in our previous studies, we undertake a characterization of the interaction on estrogenic activity of GS and VN using
in vivo
models of immature and ovariectomized (OVX) mice and
in vitro
studies with MCF-7 cells for further mechanism. VN decreased the estrogenic efficacy of GS on promoting the development of the uterus and vagina in immature mice, and reversing the atrophy of reproductive tissues in OVX mice. VN interfered with the estrogenic efficacy of GS by decreasing the increase of the serum estradiol and the up-regulation of ERα and ERβ expressions by treatment with GS. And VN antagonized the estrogenic efficacy of GS on promoting the viability of MCF-7 cells and up-regulation of protein and gene expressions of ERs. In conclusion, this study provided evidence that GS and VN decreased effects on estrogenic activity, which might be related to regulation of estrogen secretion and ERs. |
| doi_str_mv | 10.1038/srep26924 |
| format | Article |
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in vivo
models of immature and ovariectomized (OVX) mice and
in vitro
studies with MCF-7 cells for further mechanism. VN decreased the estrogenic efficacy of GS on promoting the development of the uterus and vagina in immature mice, and reversing the atrophy of reproductive tissues in OVX mice. VN interfered with the estrogenic efficacy of GS by decreasing the increase of the serum estradiol and the up-regulation of ERα and ERβ expressions by treatment with GS. And VN antagonized the estrogenic efficacy of GS on promoting the viability of MCF-7 cells and up-regulation of protein and gene expressions of ERs. In conclusion, this study provided evidence that GS and VN decreased effects on estrogenic activity, which might be related to regulation of estrogen secretion and ERs.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep26924</identifier><identifier>PMID: 27229740</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 38/77 ; 64/60 ; 692/163/2743 ; 692/700 ; 82 ; 82/1 ; Animals ; Drug Antagonism ; Drugs, Chinese Herbal ; Estradiol - blood ; Estrogen Receptor alpha - genetics ; Estrogen Receptor alpha - metabolism ; Estrogen Receptor beta - genetics ; Estrogen Receptor beta - metabolism ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - genetics ; Gene Expression Regulation ; Humanities and Social Sciences ; Humans ; Luteinizing Hormone - blood ; Luteinizing Hormone - genetics ; MCF-7 Cells ; Medicine, Chinese Traditional ; Mice ; multidisciplinary ; Ovariectomy ; Panax - chemistry ; Plant Extracts - pharmacology ; Science ; Sexual Maturation - physiology ; Uterus - drug effects ; Uterus - growth & development ; Uterus - metabolism ; Vagina - drug effects ; Vagina - growth & development ; Vagina - metabolism ; Veratrum - chemistry</subject><ispartof>Scientific reports, 2016-05, Vol.6 (1), p.26924-26924, Article 26924</ispartof><rights>The Author(s) 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-29b6fb7586c78e680f6402b6ebd9ebb24e128b1bdec70702ab5a292bbbef41be3</citedby><cites>FETCH-LOGICAL-c410t-29b6fb7586c78e680f6402b6ebd9ebb24e128b1bdec70702ab5a292bbbef41be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882595/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882595/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27229740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Ding, Jie</creatorcontrib><creatorcontrib>An, Jin-na</creatorcontrib><creatorcontrib>Qu, Ya-kun</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Ma, Xiao-ping</creatorcontrib><creatorcontrib>Zhang, Yi-min</creatorcontrib><creatorcontrib>Dai, Guo-jing</creatorcontrib><creatorcontrib>Lin, Na</creatorcontrib><title>Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in “eighteen antagonistic medicaments” that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect of GS described in our previous studies, we undertake a characterization of the interaction on estrogenic activity of GS and VN using
in vivo
models of immature and ovariectomized (OVX) mice and
in vitro
studies with MCF-7 cells for further mechanism. VN decreased the estrogenic efficacy of GS on promoting the development of the uterus and vagina in immature mice, and reversing the atrophy of reproductive tissues in OVX mice. VN interfered with the estrogenic efficacy of GS by decreasing the increase of the serum estradiol and the up-regulation of ERα and ERβ expressions by treatment with GS. And VN antagonized the estrogenic efficacy of GS on promoting the viability of MCF-7 cells and up-regulation of protein and gene expressions of ERs. In conclusion, this study provided evidence that GS and VN decreased effects on estrogenic activity, which might be related to regulation of estrogen secretion and ERs.</description><subject>13/51</subject><subject>38/77</subject><subject>64/60</subject><subject>692/163/2743</subject><subject>692/700</subject><subject>82</subject><subject>82/1</subject><subject>Animals</subject><subject>Drug Antagonism</subject><subject>Drugs, Chinese Herbal</subject><subject>Estradiol - blood</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogen Receptor beta - genetics</subject><subject>Estrogen Receptor beta - metabolism</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - genetics</subject><subject>Gene Expression Regulation</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - genetics</subject><subject>MCF-7 Cells</subject><subject>Medicine, Chinese Traditional</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Ovariectomy</subject><subject>Panax - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Science</subject><subject>Sexual Maturation - physiology</subject><subject>Uterus - drug effects</subject><subject>Uterus - growth & development</subject><subject>Uterus - metabolism</subject><subject>Vagina - drug effects</subject><subject>Vagina - growth & development</subject><subject>Vagina - metabolism</subject><subject>Veratrum - chemistry</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNptkU1PGzEQhq2qVUGUQ_9A5WOpFGrPej98qYRQ-JBQ4QBcLduZ3Zgmdmp7U_j3OApEINWXGc8883rkl5CvnB1zVnU_U8QVNBLEB7IPTNQTqAA-vsn3yGFKD6ycGqTg8jPZgxZAtoLtkz_TvkebaehpniO99BmjttkFvyndl0uO45L-dsMm_HN5Tm-014_03PmEfqAFnKYcw4DeWXpSRtcuPxUheu_WgWo_2-YF-UI-9XqR8PAlHpC7s-nt6cXk6vr88vTkamIFZ3kC0jS9aeuusW2HTcf6RjAwDZqZRGNAIIfOcDND27KWgTa1BgnGGOwFN1gdkF9b3dVoljiz6HPUC7WKbqnjkwraqfcd7-ZqCGslug5qWReB7y8CMfwdMWW1dMniYqE9hjEp3kqo2hqqpqBHW9TGkIoV_e4ZztTGH7Xzp7Df3u61I1_dKMCPLZBKyw8Y1UMYoy9_9R-1Zxy8m8I</recordid><startdate>20160527</startdate><enddate>20160527</enddate><creator>Xu, Ying</creator><creator>Ding, Jie</creator><creator>An, Jin-na</creator><creator>Qu, Ya-kun</creator><creator>Li, Xin</creator><creator>Ma, Xiao-ping</creator><creator>Zhang, Yi-min</creator><creator>Dai, Guo-jing</creator><creator>Lin, Na</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160527</creationdate><title>Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro</title><author>Xu, Ying ; Ding, Jie ; An, Jin-na ; Qu, Ya-kun ; Li, Xin ; Ma, Xiao-ping ; Zhang, Yi-min ; Dai, Guo-jing ; Lin, Na</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-29b6fb7586c78e680f6402b6ebd9ebb24e128b1bdec70702ab5a292bbbef41be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>13/51</topic><topic>38/77</topic><topic>64/60</topic><topic>692/163/2743</topic><topic>692/700</topic><topic>82</topic><topic>82/1</topic><topic>Animals</topic><topic>Drug Antagonism</topic><topic>Drugs, Chinese Herbal</topic><topic>Estradiol - blood</topic><topic>Estrogen Receptor alpha - genetics</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Estrogen Receptor beta - genetics</topic><topic>Estrogen Receptor beta - metabolism</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - genetics</topic><topic>Gene Expression Regulation</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - genetics</topic><topic>MCF-7 Cells</topic><topic>Medicine, Chinese Traditional</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Ovariectomy</topic><topic>Panax - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Science</topic><topic>Sexual Maturation - physiology</topic><topic>Uterus - drug effects</topic><topic>Uterus - growth & development</topic><topic>Uterus - metabolism</topic><topic>Vagina - drug effects</topic><topic>Vagina - growth & development</topic><topic>Vagina - metabolism</topic><topic>Veratrum - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Ding, Jie</creatorcontrib><creatorcontrib>An, Jin-na</creatorcontrib><creatorcontrib>Qu, Ya-kun</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Ma, Xiao-ping</creatorcontrib><creatorcontrib>Zhang, Yi-min</creatorcontrib><creatorcontrib>Dai, Guo-jing</creatorcontrib><creatorcontrib>Lin, Na</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ying</au><au>Ding, Jie</au><au>An, Jin-na</au><au>Qu, Ya-kun</au><au>Li, Xin</au><au>Ma, Xiao-ping</au><au>Zhang, Yi-min</au><au>Dai, Guo-jing</au><au>Lin, Na</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-05-27</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>26924</spage><epage>26924</epage><pages>26924-26924</pages><artnum>26924</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in “eighteen antagonistic medicaments” that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect of GS described in our previous studies, we undertake a characterization of the interaction on estrogenic activity of GS and VN using
in vivo
models of immature and ovariectomized (OVX) mice and
in vitro
studies with MCF-7 cells for further mechanism. VN decreased the estrogenic efficacy of GS on promoting the development of the uterus and vagina in immature mice, and reversing the atrophy of reproductive tissues in OVX mice. VN interfered with the estrogenic efficacy of GS by decreasing the increase of the serum estradiol and the up-regulation of ERα and ERβ expressions by treatment with GS. And VN antagonized the estrogenic efficacy of GS on promoting the viability of MCF-7 cells and up-regulation of protein and gene expressions of ERs. In conclusion, this study provided evidence that GS and VN decreased effects on estrogenic activity, which might be related to regulation of estrogen secretion and ERs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27229740</pmid><doi>10.1038/srep26924</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/51 38/77 64/60 692/163/2743 692/700 82 82/1 Animals Drug Antagonism Drugs, Chinese Herbal Estradiol - blood Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - genetics Gene Expression Regulation Humanities and Social Sciences Humans Luteinizing Hormone - blood Luteinizing Hormone - genetics MCF-7 Cells Medicine, Chinese Traditional Mice multidisciplinary Ovariectomy Panax - chemistry Plant Extracts - pharmacology Science Sexual Maturation - physiology Uterus - drug effects Uterus - growth & development Uterus - metabolism Vagina - drug effects Vagina - growth & development Vagina - metabolism Veratrum - chemistry |
| title | Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro |
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