Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes
Objective To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/d...
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| Veröffentlicht in: | Pediatric diabetes 2016-12, Vol.17 (8), p.584-591 |
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| creator | Wood, Jamie R. Connor, Crystal G. Cheng, Peiyao Ruedy, Katrina J. Tamborlane, William V. Klingensmith, Georgeanna Schatz, Desmond Gregg, Brigid Cengiz, Eda Willi, Steven Bacha, Fida Beck, Roy W. |
| description | Objective
To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/demographic factors and vitamin D levels.
Methods
25‐hydroxy vitamin D (25OHD) levels were measured in 215 youth with T1D and 326 youth with T2D enrolled in the Pediatric Diabetes Consortium (PDC). These levels were compared with those of youth of the same age without diabetes from the 2005–2006 NHANES Survey.
Results
Vitamin D deficiency ( |
| doi_str_mv | 10.1111/pedi.12340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4882286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826636468</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5260-924a16139cfcce4d2617fd9eb486cba103c5450f0ad5826ad658e16d87652fc93</originalsourceid><addsrcrecordid>eNqNUstu1DAUjRCIPmDDByAvyyLFrzjOBgnNtNOXyggBZWd57BvGkMRD7HQ6n8Lf4um0Ed3hhX2ke865x7o3y94QfEzSeb8C644JZRw_y_YJq6q84Fw-HzH7vpcdhPATY1JWjL_M9qgQhMgK72d_vrmoW9ehKQpRxyGghDd-iEu0dumKmxUggnRnd5Ai6_QCIgQEXe-bBuxWEZeA5imGjr0zaPpImfgu-D66oUVH8-nkHXIBdT6ite8DJJHunrZLYPR_lb2odRPg9cN7mH09PfkyOcuvPs3OJx-vclNQgfOKck1E-qmpjQFuqSBlbStYcCnMQhPMTMELXGNtC0mFtqKQQISVpShobSp2mH3Y-a6GRQvWQBd73ahV71rdb5TXTj2tdG6pfvhbxaWkVIpkcPRg0PvfA4SoWhcMNI3uwA9BEckFq0pJq_-gpskwwYVM1Lf_xhrzPI4uEciOsHYNbMY6wWq7FGq7FOp-KdT8ZHp-j5Im32lciHA3anT_S4mSlYW6uZ6pi_nn2eXZxY3i7C-C77sr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826636468</pqid></control><display><type>article</type><title>Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wood, Jamie R. ; Connor, Crystal G. ; Cheng, Peiyao ; Ruedy, Katrina J. ; Tamborlane, William V. ; Klingensmith, Georgeanna ; Schatz, Desmond ; Gregg, Brigid ; Cengiz, Eda ; Willi, Steven ; Bacha, Fida ; Beck, Roy W.</creator><creatorcontrib>Wood, Jamie R. ; Connor, Crystal G. ; Cheng, Peiyao ; Ruedy, Katrina J. ; Tamborlane, William V. ; Klingensmith, Georgeanna ; Schatz, Desmond ; Gregg, Brigid ; Cengiz, Eda ; Willi, Steven ; Bacha, Fida ; Beck, Roy W. ; Pediatric Diabetes Consortium</creatorcontrib><description>Objective
To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/demographic factors and vitamin D levels.
Methods
25‐hydroxy vitamin D (25OHD) levels were measured in 215 youth with T1D and 326 youth with T2D enrolled in the Pediatric Diabetes Consortium (PDC). These levels were compared with those of youth of the same age without diabetes from the 2005–2006 NHANES Survey.
Results
Vitamin D deficiency (<21 ng/mL) was present in 36% of PDC participants, and insufficiency (21–29 ng/mL) was present in an additional 34%. About 36% of age‐matched youth in the NHANES Survey were vitamin D deficient and an additional 41% were insufficient. Deficiency or insufficiency varied by race/ethnicity, being highest in African–Americans (86%), intermediate in Hispanics (77%), and lowest in non‐Hispanic whites (47%). Lower 25OHD levels were observed in African–American and Hispanic youth, during fall and winter, and at sites in the northern United States (all p‐values < 0.001). Youth with T2D had significantly lower 25OHD levels than youth with T1D (p < 0.001), but this difference was largely eliminated after adjusting for race/ethnicity and socio‐economic status.
Conclusions
Vitamin D deficiency/insufficiency is present in a substantial proportion of youth with diabetes, particularly minorities, but the prevalence appears similar to that in youth without diabetes. Further studies are needed to examine whether youth with diabetes would benefit from vitamin D supplementation.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/pedi.12340</identifier><identifier>PMID: 26611890</identifier><language>eng</language><publisher>Former Munksgaard: John Wiley & Sons A/S</publisher><subject>Adolescent ; Child ; Cohort Studies ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Humans ; Male ; Nutrition Surveys ; Nutritional Status ; pediatrics ; Prevalence ; T1D ; T2D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology</subject><ispartof>Pediatric diabetes, 2016-12, Vol.17 (8), p.584-591</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5260-924a16139cfcce4d2617fd9eb486cba103c5450f0ad5826ad658e16d87652fc93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpedi.12340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpedi.12340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26611890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Jamie R.</creatorcontrib><creatorcontrib>Connor, Crystal G.</creatorcontrib><creatorcontrib>Cheng, Peiyao</creatorcontrib><creatorcontrib>Ruedy, Katrina J.</creatorcontrib><creatorcontrib>Tamborlane, William V.</creatorcontrib><creatorcontrib>Klingensmith, Georgeanna</creatorcontrib><creatorcontrib>Schatz, Desmond</creatorcontrib><creatorcontrib>Gregg, Brigid</creatorcontrib><creatorcontrib>Cengiz, Eda</creatorcontrib><creatorcontrib>Willi, Steven</creatorcontrib><creatorcontrib>Bacha, Fida</creatorcontrib><creatorcontrib>Beck, Roy W.</creatorcontrib><creatorcontrib>Pediatric Diabetes Consortium</creatorcontrib><title>Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Objective
To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/demographic factors and vitamin D levels.
Methods
25‐hydroxy vitamin D (25OHD) levels were measured in 215 youth with T1D and 326 youth with T2D enrolled in the Pediatric Diabetes Consortium (PDC). These levels were compared with those of youth of the same age without diabetes from the 2005–2006 NHANES Survey.
Results
Vitamin D deficiency (<21 ng/mL) was present in 36% of PDC participants, and insufficiency (21–29 ng/mL) was present in an additional 34%. About 36% of age‐matched youth in the NHANES Survey were vitamin D deficient and an additional 41% were insufficient. Deficiency or insufficiency varied by race/ethnicity, being highest in African–Americans (86%), intermediate in Hispanics (77%), and lowest in non‐Hispanic whites (47%). Lower 25OHD levels were observed in African–American and Hispanic youth, during fall and winter, and at sites in the northern United States (all p‐values < 0.001). Youth with T2D had significantly lower 25OHD levels than youth with T1D (p < 0.001), but this difference was largely eliminated after adjusting for race/ethnicity and socio‐economic status.
Conclusions
Vitamin D deficiency/insufficiency is present in a substantial proportion of youth with diabetes, particularly minorities, but the prevalence appears similar to that in youth without diabetes. Further studies are needed to examine whether youth with diabetes would benefit from vitamin D supplementation.</description><subject>Adolescent</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nutrition Surveys</subject><subject>Nutritional Status</subject><subject>pediatrics</subject><subject>Prevalence</subject><subject>T1D</subject><subject>T2D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>vitamin D deficiency</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUstu1DAUjRCIPmDDByAvyyLFrzjOBgnNtNOXyggBZWd57BvGkMRD7HQ6n8Lf4um0Ed3hhX2ke865x7o3y94QfEzSeb8C644JZRw_y_YJq6q84Fw-HzH7vpcdhPATY1JWjL_M9qgQhMgK72d_vrmoW9ehKQpRxyGghDd-iEu0dumKmxUggnRnd5Ai6_QCIgQEXe-bBuxWEZeA5imGjr0zaPpImfgu-D66oUVH8-nkHXIBdT6ite8DJJHunrZLYPR_lb2odRPg9cN7mH09PfkyOcuvPs3OJx-vclNQgfOKck1E-qmpjQFuqSBlbStYcCnMQhPMTMELXGNtC0mFtqKQQISVpShobSp2mH3Y-a6GRQvWQBd73ahV71rdb5TXTj2tdG6pfvhbxaWkVIpkcPRg0PvfA4SoWhcMNI3uwA9BEckFq0pJq_-gpskwwYVM1Lf_xhrzPI4uEciOsHYNbMY6wWq7FGq7FOp-KdT8ZHp-j5Im32lciHA3anT_S4mSlYW6uZ6pi_nn2eXZxY3i7C-C77sr</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Wood, Jamie R.</creator><creator>Connor, Crystal G.</creator><creator>Cheng, Peiyao</creator><creator>Ruedy, Katrina J.</creator><creator>Tamborlane, William V.</creator><creator>Klingensmith, Georgeanna</creator><creator>Schatz, Desmond</creator><creator>Gregg, Brigid</creator><creator>Cengiz, Eda</creator><creator>Willi, Steven</creator><creator>Bacha, Fida</creator><creator>Beck, Roy W.</creator><general>John Wiley & Sons A/S</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201612</creationdate><title>Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes</title><author>Wood, Jamie R. ; Connor, Crystal G. ; Cheng, Peiyao ; Ruedy, Katrina J. ; Tamborlane, William V. ; Klingensmith, Georgeanna ; Schatz, Desmond ; Gregg, Brigid ; Cengiz, Eda ; Willi, Steven ; Bacha, Fida ; Beck, Roy W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5260-924a16139cfcce4d2617fd9eb486cba103c5450f0ad5826ad658e16d87652fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nutrition Surveys</topic><topic>Nutritional Status</topic><topic>pediatrics</topic><topic>Prevalence</topic><topic>T1D</topic><topic>T2D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Jamie R.</creatorcontrib><creatorcontrib>Connor, Crystal G.</creatorcontrib><creatorcontrib>Cheng, Peiyao</creatorcontrib><creatorcontrib>Ruedy, Katrina J.</creatorcontrib><creatorcontrib>Tamborlane, William V.</creatorcontrib><creatorcontrib>Klingensmith, Georgeanna</creatorcontrib><creatorcontrib>Schatz, Desmond</creatorcontrib><creatorcontrib>Gregg, Brigid</creatorcontrib><creatorcontrib>Cengiz, Eda</creatorcontrib><creatorcontrib>Willi, Steven</creatorcontrib><creatorcontrib>Bacha, Fida</creatorcontrib><creatorcontrib>Beck, Roy W.</creatorcontrib><creatorcontrib>Pediatric Diabetes Consortium</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Jamie R.</au><au>Connor, Crystal G.</au><au>Cheng, Peiyao</au><au>Ruedy, Katrina J.</au><au>Tamborlane, William V.</au><au>Klingensmith, Georgeanna</au><au>Schatz, Desmond</au><au>Gregg, Brigid</au><au>Cengiz, Eda</au><au>Willi, Steven</au><au>Bacha, Fida</au><au>Beck, Roy W.</au><aucorp>Pediatric Diabetes Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2016-12</date><risdate>2016</risdate><volume>17</volume><issue>8</issue><spage>584</spage><epage>591</epage><pages>584-591</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Objective
To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/demographic factors and vitamin D levels.
Methods
25‐hydroxy vitamin D (25OHD) levels were measured in 215 youth with T1D and 326 youth with T2D enrolled in the Pediatric Diabetes Consortium (PDC). These levels were compared with those of youth of the same age without diabetes from the 2005–2006 NHANES Survey.
Results
Vitamin D deficiency (<21 ng/mL) was present in 36% of PDC participants, and insufficiency (21–29 ng/mL) was present in an additional 34%. About 36% of age‐matched youth in the NHANES Survey were vitamin D deficient and an additional 41% were insufficient. Deficiency or insufficiency varied by race/ethnicity, being highest in African–Americans (86%), intermediate in Hispanics (77%), and lowest in non‐Hispanic whites (47%). Lower 25OHD levels were observed in African–American and Hispanic youth, during fall and winter, and at sites in the northern United States (all p‐values < 0.001). Youth with T2D had significantly lower 25OHD levels than youth with T1D (p < 0.001), but this difference was largely eliminated after adjusting for race/ethnicity and socio‐economic status.
Conclusions
Vitamin D deficiency/insufficiency is present in a substantial proportion of youth with diabetes, particularly minorities, but the prevalence appears similar to that in youth without diabetes. Further studies are needed to examine whether youth with diabetes would benefit from vitamin D supplementation.</abstract><cop>Former Munksgaard</cop><pub>John Wiley & Sons A/S</pub><pmid>26611890</pmid><doi>10.1111/pedi.12340</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1399-543X |
| ispartof | Pediatric diabetes, 2016-12, Vol.17 (8), p.584-591 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Child Cohort Studies Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Female Humans Male Nutrition Surveys Nutritional Status pediatrics Prevalence T1D T2D Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology |
| title | Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes |
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