Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric disease that causes neuronal death and is characterized by progressive striatal and then widespread brain atrophy. Brain-derived neurotrophic factor (BDNF) is a lead candidate for the treatment of HD, as it ha...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular therapy 2016-05, Vol.24 (5), p.965-977
Hauptverfasser:	Pollock, Kari, Dahlenburg, Heather, Nelson, Haley, Fink, Kyle D, Cary, Whitney, Hendrix, Kyle, Annett, Geralyn, Torrest, Audrey, Deng, Peter, Gutierrez, Joshua, Nacey, Catherine, Pepper, Karen, Kalomoiris, Stefanos, Anderson, Johnathon D, McGee, Jeannine, Gruenloh, William, Fury, Brian, Bauer, Gerhard, Duffy, Alexandria, Tempkin, Theresa, Wheelock, Vicki, Nolta, Jan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Anxiety Atrophy Brain-derived neurotrophic factor Cell death Huntingtons disease Neurogenesis Original Proteins Stem cells Vectors (Biology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!