Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

Clinical application of umbilical cord blood (UCB) as a source of hematopoietic stem cells for transplantation is limited by low CD34+ cell dose, increased risk of graft failure, and slow hematopoietic recovery. While the cell dose limitation is partially mitigated by using two UCB units, larger-dos...

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Veröffentlicht in:	Cell stem cell 2016-01, Vol.18 (1), p.144-155
Hauptverfasser:	Wagner, John E., Brunstein, Claudio G., Boitano, Anthony E., DeFor, Todd E., McKenna, David, Sumstad, Darin, Blazar, Bruce R., Tolar, Jakub, Le, Chap, Jones, Julie, Cooke, Michael P., Bleul, Conrad C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigens, CD34 - metabolism Blood Platelets - cytology Cells, Cultured Child Cord Blood Stem Cell Transplantation Cryopreservation Fetal Blood - cytology Graft Survival Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology HLA Antigens - metabolism Humans Middle Aged Neutrophils - cytology Purines - chemistry T-Lymphocytes - cytology Telomere - ultrastructure Transplantation Conditioning Young Adult
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