Cannabis and tolerance: acute drug impairment as a function of cannabis use history
Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users...
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| Veröffentlicht in: | Scientific reports 2016-05, Vol.6 (1), p.26843, Article 26843 |
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| creator | Ramaekers, J. G. van Wel, J. H. Spronk, D. B. Toennes, S. W. Kuypers, K. P. C. Theunissen, E. L. Verkes, R. J. |
| description | Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic. |
| doi_str_mv | 10.1038/srep26843 |
| format | Article |
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Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep26843</identifier><identifier>PMID: 27225696</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378 ; 631/477 ; Acute effects ; Cannabis ; Cocaine ; Cognition ; Drug abuse ; Executive function ; Humanities and Social Sciences ; Impulsive behavior ; Intoxication ; Marijuana ; multidisciplinary ; Science ; Science (multidisciplinary) ; Tetrahydrocannabinol</subject><ispartof>Scientific reports, 2016-05, Vol.6 (1), p.26843, Article 26843</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group May 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-3b6c1f2117f23ba178ea5febbfc7f228efef301e3d6ed838ccb07df41fc70e963</citedby><cites>FETCH-LOGICAL-c438t-3b6c1f2117f23ba178ea5febbfc7f228efef301e3d6ed838ccb07df41fc70e963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881034/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881034/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27225696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramaekers, J. 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| subjects | 631/378 631/477 Acute effects Cannabis Cocaine Cognition Drug abuse Executive function Humanities and Social Sciences Impulsive behavior Intoxication Marijuana multidisciplinary Science Science (multidisciplinary) Tetrahydrocannabinol |
| title | Cannabis and tolerance: acute drug impairment as a function of cannabis use history |
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