Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity

Piscidin-1 possesses significant antimicrobial and cytotoxic activities. To recognize the primary amino acid sequence(s) in piscidin-1 that could be important for its biological activity, a long heptad repeat sequence located in the region from amino acids 2 to 19 was identified. To comprehend the p...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-06, Vol.60 (6), p.3687-3699
Hauptverfasser:	Kumar, Amit, Tripathi, Amit Kumar, Kathuria, Manoj, Shree, Sonal, Tripathi, Jitendra Kumar, Purshottam, R K, Ramachandran, Ravishankar, Mitra, Kalyan, Ghosh, Jimut Kanti
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Anti-Infective Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antimicrobial Cationic Peptides Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Cell Line Cell Membrane - chemistry Cell Membrane - drug effects Drug Design Erythrocytes - cytology Erythrocytes - drug effects Experimental Therapeutics Female Fish Proteins Fish Proteins - chemical synthesis Fish Proteins - chemistry Fish Proteins - pharmacology Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - growth & development Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - growth & development Hemolysis - drug effects Humans Lipopolysaccharides Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - drug effects Mice Mice, Inbred BALB C Microbial Sensitivity Tests Peritonitis Peritonitis - chemically induced Peritonitis - mortality Peritonitis - pathology Peritonitis - prevention & control Protein Engineering Protein Structure, Secondary Structure-Activity Relationship Survival Analysis
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