Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

The inflammasome is hypothesized to be a key mediator of the response to physiological and psychological stressors, and its dysregulation may be implicated in major depressive disorder. Inflammasome activation causes the maturation of caspase-1 and activation of interleukin (IL)-1β and IL-18, two pr...

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Veröffentlicht in:	Molecular psychiatry 2016-06, Vol.21 (6), p.797-805
Hauptverfasser:	Wong, M-L, Inserra, A, Lewis, M D, Mastronardi, C A, Leong, L, Choo, J, Kentish, S, Xie, P, Morrison, M, Wesselingh, S L, Rogers, G B, Licinio, J
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 45/41 631/378 64/110 64/60 692/699/476/1414 Animals Anxiety Anxiety - metabolism Anxiety Disorders - complications Behavior, Animal - physiology Behavioral Sciences Biological Psychology Brain - metabolism Caspase 1 Cytokines - metabolism Depression - metabolism Depression, Mental Depressive Disorder, Major - metabolism Gastrointestinal Microbiome - immunology Gastrointestinal Microbiome - physiology Health aspects Inflammasomes - metabolism Inflammasomes - physiology Inflammation - metabolism Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Minocycline Neuroimmunomodulation - physiology Neurosciences Original original-article Pharmacotherapy Physiological aspects Psychiatry Signal Transduction Stress (Psychology) Stress, Psychological - microbiology
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