Mechanism of Human Nucleocytoplasmic Hexosaminidase D

Mammalian β-hexosaminidases have been shown to play essential roles in cellular physiology and health. These enzymes are responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. One of these β-hexosaminidases, hexos...

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Veröffentlicht in:	Biochemistry (Easton) 2016-05, Vol.55 (19), p.2735-2747
Hauptverfasser:	Alteen, Matthew G, Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B. H, Vocadlo, David J, Gloster, Tracey M
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Enzyme Inhibitors - chemistry Hexosaminidases - antagonists & inhibitors Hexosaminidases - chemistry Hexosaminidases - genetics Hexosaminidases - metabolism Humans Hydrogen-Ion Concentration Hydrolysis Kinetics Thiazolidines - chemistry
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