The ability of inner cell mass cells to self-renew as embryonic stem cells is acquired upon epiblast specification

The precise relationship of embryonic stem cells (ESC) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESC. Marker profiling shows that ESC are distinct from early inner cell mass (ICM) and closely resemble p...

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Veröffentlicht in:	Nature cell biology 2014-05, Vol.16 (6), p.516-528
Hauptverfasser:	Boroviak, Thorsten, Loos, Remco, Bertone, Paul, Smith, Austin, Nichols, Jennifer
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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