Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats

The endoplasmic reticulum (ER) is an organelle in which proteins form their appropriate structures. However, several of these proteins become unfolded or misfolded when exposed to stimuli, including hyperglycemia, oxidative stress, ischemia, disturbance of calcium homeostasis and overexpression of a...

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Veröffentlicht in:	Molecular medicine reports 2016-06, Vol.13 (6), p.5037-5044
Hauptverfasser:	YANG, QIONG, GAO, HUIKUAN, DONG, RUIQING, WU, YONG-QUAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Animals Apoptosis Biomarkers Calcium homeostasis Cardiomyopathies - diagnosis Cardiomyopathies - etiology Cardiomyopathies - metabolism Cardiovascular disease Care and treatment Complications and side effects Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Experimental Disease Models, Animal eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress Fibrosis Gene Expression Genetic aspects Health aspects Heart diseases Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Homeostasis Hyperglycemia Ischemia JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Kinases Male myocardial fibrosis Myocardium - metabolism Myocardium - pathology Organ Size Oxidative Stress Polymerase chain reaction Protein folding Rats RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stroke Volume Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Unfolded Protein Response Western blotting
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