Sex‐dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic‐ischemic encephalopathy

Increased male susceptibility to long‐term cognitive deficits is well described in clinical and experimental studies of neonatal hypoxic‐ischemic encephalopathy. While cell death signaling pathways are known to be sexually dimorphic, a sex‐dependent pathophysiological mechanism preceding the majorit...

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Veröffentlicht in:	Journal of neurochemistry 2016-06, Vol.137 (5), p.714-729
Hauptverfasser:	Demarest, Tyler G., Schuh, Rosemary A., Waddell, Jaylyn, McKenna, Mary C., Fiskum, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Disease Models, Animal Encephalitis Female glutathione glutathione peroxidase Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - pathology Ischemia Male Mitochondria - metabolism Mitochondria - pathology Neurochemistry oxidative phosphorylation Oxidative stress Oxidative Stress - physiology Oxygen Consumption - physiology protein carbonyl Proteins Rats Rats, Sprague-Dawley Rodents Sex Characteristics
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