Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models

Caspases work as a double-edged sword in maintaining cell homeostasis. Highly regulated caspase activities are essential during animal development, but dysregulation might lead to different diseases, e.g. extreme caspase activation is known to promote neurodegeneration. At present, visualization of...

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Veröffentlicht in:	Scientific reports 2016-05, Vol.6 (1), p.26385, Article 26385
Hauptverfasser:	Qian, Linghui, Zhang, Cheng-Wu, Mao, Yanli, Li, Lin, Gao, Nengyue, Lim, Kah-Leong, Xu, Qing-Hua, Yao, Shao Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 14/34 631/92/607/468 631/92/613 631/92/96 64/60 96/2 96/34 Animals Brain - enzymology Caspase Caspases - chemistry Caspases - metabolism Cell Line Enzymes HeLa Cells Homeostasis Humanities and Social Sciences Humans Mammalian cells Microscopy, Fluorescence, Multiphoton Models, Biological Molecular Probes - chemistry multidisciplinary Neurodegeneration Neuroimaging Organelles Probes Rats Science Science (multidisciplinary) Toxicity
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