Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer

Induction chemotherapy (IC) before radiotherapy lowers distant failure (DF) rates in locally advanced squamous cell carcinoma of the head and neck (SCCHN). The goal of this phase III trial was to determine whether IC before chemoradiotherapy (CRT) further improves survival compared with CRT alone in...

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Veröffentlicht in:	Journal of clinical oncology 2014-09, Vol.32 (25), p.2735-2743
Hauptverfasser:	Cohen, Ezra E W, Karrison, Theodore G, Kocherginsky, Masha, Mueller, Jeffrey, Egan, Robyn, Huang, Chao H, Brockstein, Bruce E, Agulnik, Mark B, Mittal, Bharat B, Yunus, Furhan, Samant, Sandeep, Raez, Luis E, Mehra, Ranee, Kumar, Priya, Ondrey, Frank, Marchand, Patrice, Braegas, Bettina, Seiwert, Tanguy Y, Villaflor, Victoria M, Haraf, Daniel J, Vokes, Everett E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brazil Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Chemoradiotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Docetaxel Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - radiotherapy Humans Hydroxyurea - administration & dosage Hydroxyurea - adverse effects Induction Chemotherapy Male Middle Aged ORIGINAL REPORTS Squamous Cell Carcinoma of Head and Neck Survival Rate Taxoids - administration & dosage Taxoids - adverse effects
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