Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats
Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments. In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2016-05, Vol.16 (135), p.135, Article 135 |
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| creator | Taher, Muhammad Tg Zakaria, Tg Muhamad Faris Syafiq Susanti, Deny Zakaria, Zainul Amiruddin |
| description | Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments. In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats.
GME at 2,000 mg/kg was subjected to a single-dose acute toxicity test. Following this, the effect of GME (50, 100, and 200 mg/kg) on blood glucose level of normoglycaemic and STZ-induced diabetic rats was determined using single-dose (acute) and multiple-dose (subacute) approaches. Subsequent to the multiple-dose study, serum biochemical analysis and liver histopathological examination were also performed. Throughout the experiments, the effect of GME was compared against the standard hypoglycaemic drug, glibenclamide.
GME was safe for oral consumption up to the dose of 2,000 mg/kg. In both single- and multiple-dose studies, GME significantly (p |
| doi_str_mv | 10.1186/s12906-016-1118-9 |
| format | Article |
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GME at 2,000 mg/kg was subjected to a single-dose acute toxicity test. Following this, the effect of GME (50, 100, and 200 mg/kg) on blood glucose level of normoglycaemic and STZ-induced diabetic rats was determined using single-dose (acute) and multiple-dose (subacute) approaches. Subsequent to the multiple-dose study, serum biochemical analysis and liver histopathological examination were also performed. Throughout the experiments, the effect of GME was compared against the standard hypoglycaemic drug, glibenclamide.
GME was safe for oral consumption up to the dose of 2,000 mg/kg. In both single- and multiple-dose studies, GME significantly (p < 0.05) reduced the blood glucose level in normoglycaemic rats and STZ-induced diabetic rats when compared against the normal control group or diabetic control group, respectively. Moreover, GME also significantly (p < 0.05) increased the rats' body weight in comparison to the diabetic control group in the multiple-dose study. GME also significantly (p < 0.05) reduced the levels of certain biochemical parameters [i.e., triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), urea, and creatinine] while increased the others [i.e., high density lipoprotein (HDL) and total protein (TP)] when compared to the diabetic control group. Histopathological assessment of the collected liver revealed a mild increase in the population of β-cells in the diabetic rats.
GME exerts the hypoglycaemic activity possibly by increasing the population of insulin-producing β-cells. This activity could be attributed to the presence of antioxidant-bearing tannins like epicathecin, and xanthones like α-mangostin. Thus, the findings demonstrated that GME could be a potential candidate in the management of diabetes owing to its hypoglycaemic effect.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/s12906-016-1118-9</identifier><identifier>PMID: 27208974</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Antioxidants ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Dose-Response Relationship, Drug ; Ethanol ; Garcinia mangostana - chemistry ; Garcinia mangostana - toxicity ; Glyburide - therapeutic use ; Health aspects ; Hypoglycemic Agents - therapeutic use ; Hypoglycemic Agents - toxicity ; Low density lipoproteins ; Male ; Mangosteen ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Rats ; Rats, Sprague-Dawley</subject><ispartof>BMC complementary and alternative medicine, 2016-05, Vol.16 (135), p.135, Article 135</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Taher et al. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-44f1bb8abdae6d2b83f683feb65c4e523bd8505e59def422c3a89b23c9dffd793</citedby><cites>FETCH-LOGICAL-c525t-44f1bb8abdae6d2b83f683feb65c4e523bd8505e59def422c3a89b23c9dffd793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875614/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875614/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27208974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taher, Muhammad</creatorcontrib><creatorcontrib>Tg Zakaria, Tg Muhamad Faris Syafiq</creatorcontrib><creatorcontrib>Susanti, Deny</creatorcontrib><creatorcontrib>Zakaria, Zainul Amiruddin</creatorcontrib><title>Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments. In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats.
GME at 2,000 mg/kg was subjected to a single-dose acute toxicity test. Following this, the effect of GME (50, 100, and 200 mg/kg) on blood glucose level of normoglycaemic and STZ-induced diabetic rats was determined using single-dose (acute) and multiple-dose (subacute) approaches. Subsequent to the multiple-dose study, serum biochemical analysis and liver histopathological examination were also performed. Throughout the experiments, the effect of GME was compared against the standard hypoglycaemic drug, glibenclamide.
GME was safe for oral consumption up to the dose of 2,000 mg/kg. In both single- and multiple-dose studies, GME significantly (p < 0.05) reduced the blood glucose level in normoglycaemic rats and STZ-induced diabetic rats when compared against the normal control group or diabetic control group, respectively. Moreover, GME also significantly (p < 0.05) increased the rats' body weight in comparison to the diabetic control group in the multiple-dose study. GME also significantly (p < 0.05) reduced the levels of certain biochemical parameters [i.e., triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), urea, and creatinine] while increased the others [i.e., high density lipoprotein (HDL) and total protein (TP)] when compared to the diabetic control group. Histopathological assessment of the collected liver revealed a mild increase in the population of β-cells in the diabetic rats.
GME exerts the hypoglycaemic activity possibly by increasing the population of insulin-producing β-cells. This activity could be attributed to the presence of antioxidant-bearing tannins like epicathecin, and xanthones like α-mangostin. Thus, the findings demonstrated that GME could be a potential candidate in the management of diabetes owing to its hypoglycaemic effect.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol</subject><subject>Garcinia mangostana - chemistry</subject><subject>Garcinia mangostana - toxicity</subject><subject>Glyburide - therapeutic use</subject><subject>Health aspects</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Hypoglycemic Agents - toxicity</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Mangosteen</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUtFqFDEUHUSxtfoBvsiA4NusSSaZSV6EUmwrLPiizyGT3OymzCRrkildX_3xZthad0FCSDj3nMO9l1NV7zFaYcy7zwkTgboG4a7BBWjEi-oc0540Hefk5dH_rHqT0h1CuOeYvq7OSE8QFz09r_7c7ndhM-61gsnpWuns7l3e18HWkLfKh7Gg8JBjqSzgjYraeafqSflNSFl5Va-d96va-dqHOB2beVOnHGGXw--QQ9E1zptZg6mNUwPkwokqp7fVK6vGBO-e3ovq5_XXH1e3zfr7zbery3WjGWG5odTiYeBqMAo6Qwbe2q5cGDqmKTDSDoYzxIAJA5YSolvFxUBaLYy1phftRfXl4LubhwmMBl_GGuUuuknFvQzKydOKd1u5CfeS8p51mBaDj08GMfyaIWV5F-boS88S96JvCcJU_GNt1AjSeRuW7U0uaXlJGeGC4ZYX1uo_rHLMsrvgwbqCnwg-HQm2oMa8TWGcsws-nRLxgahjSCmCfZ4QI7nkRh5yI0tu5JIbufT84Xg1z4q_QWkfAXMhwP0</recordid><startdate>20160521</startdate><enddate>20160521</enddate><creator>Taher, Muhammad</creator><creator>Tg Zakaria, Tg Muhamad Faris Syafiq</creator><creator>Susanti, Deny</creator><creator>Zakaria, Zainul Amiruddin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20160521</creationdate><title>Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats</title><author>Taher, Muhammad ; 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In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats.
GME at 2,000 mg/kg was subjected to a single-dose acute toxicity test. Following this, the effect of GME (50, 100, and 200 mg/kg) on blood glucose level of normoglycaemic and STZ-induced diabetic rats was determined using single-dose (acute) and multiple-dose (subacute) approaches. Subsequent to the multiple-dose study, serum biochemical analysis and liver histopathological examination were also performed. Throughout the experiments, the effect of GME was compared against the standard hypoglycaemic drug, glibenclamide.
GME was safe for oral consumption up to the dose of 2,000 mg/kg. In both single- and multiple-dose studies, GME significantly (p < 0.05) reduced the blood glucose level in normoglycaemic rats and STZ-induced diabetic rats when compared against the normal control group or diabetic control group, respectively. Moreover, GME also significantly (p < 0.05) increased the rats' body weight in comparison to the diabetic control group in the multiple-dose study. GME also significantly (p < 0.05) reduced the levels of certain biochemical parameters [i.e., triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), urea, and creatinine] while increased the others [i.e., high density lipoprotein (HDL) and total protein (TP)] when compared to the diabetic control group. Histopathological assessment of the collected liver revealed a mild increase in the population of β-cells in the diabetic rats.
GME exerts the hypoglycaemic activity possibly by increasing the population of insulin-producing β-cells. This activity could be attributed to the presence of antioxidant-bearing tannins like epicathecin, and xanthones like α-mangostin. Thus, the findings demonstrated that GME could be a potential candidate in the management of diabetes owing to its hypoglycaemic effect.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27208974</pmid><doi>10.1186/s12906-016-1118-9</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antioxidants Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Dose-Response Relationship, Drug Ethanol Garcinia mangostana - chemistry Garcinia mangostana - toxicity Glyburide - therapeutic use Health aspects Hypoglycemic Agents - therapeutic use Hypoglycemic Agents - toxicity Low density lipoproteins Male Mangosteen Plant Extracts - therapeutic use Plant Extracts - toxicity Rats Rats, Sprague-Dawley |
| title | Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats |
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