Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease

C-reactive protein (CRP) as an indicator of cardiovascular disease (CVD) has shown limited sensitivity. We demonstrate that two isoforms of CRP (pentameric, pCRP and monomeric, mCRP) present in soluble form or on microparticles (MPs) have different biological effects and are not all measured by clin...

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Veröffentlicht in:	Journal of cardiovascular translational research 2016-06, Vol.9 (3), p.184-193
Hauptverfasser:	Crawford, Jeffrey R., Trial, JoAnn, Nambi, Vijay, Hoogeveen, Ron C., Taffet, George E., Entman, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Biomedical Engineering and Bioengineering Biomedicine C-Reactive Protein - metabolism Cardiology Case-Control Studies Cell-Derived Microparticles - drug effects Cell-Derived Microparticles - metabolism Cells, Cultured Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Human Genetics Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Mediators - blood Male Medicine Medicine & Public Health Middle Aged Original Article Peripheral Arterial Disease - blood Peripheral Arterial Disease - diagnosis Peripheral Arterial Disease - drug therapy Pilot Projects Up-Regulation
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