Progressive Early Breakdown of Retinal Pigment Epithelium Function in Hyperglycemic Rats

Diabetic macular edema (DME), an accumulation of fluid in the subretinal space, is a significant cause of vision loss. The impact of diabetes on the breakdown of the inner blood-retina barrier (BRB) is an established event that leads to DME. However, the role of the outer BRB in ocular diabetes has...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2016-05, Vol.57 (6), p.2706-2713
Hauptverfasser:	Desjardins, Danielle M, Yates, Phil W, Dahrouj, Mohammad, Liu, Yueying, Crosson, Craig E, Ablonczy, Zsolt
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Animals Bevacizumab - administration & dosage Blood-Retinal Barrier - drug effects Blood-Retinal Barrier - metabolism Cells, Cultured Chronic Disease Diabetes Mellitus, Experimental Diabetic Retinopathy - complications Diabetic Retinopathy - drug therapy Diabetic Retinopathy - metabolism Fluorescein Angiography Fundus Oculi Hyperglycemia - complications Hyperglycemia - diagnosis Immunoblotting Immunohistochemistry Intravitreal Injections Macular Edema - drug therapy Macular Edema - etiology Macular Edema - metabolism Rats Rats, Inbred BN Retina Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Retinal Vessels - metabolism Retinal Vessels - pathology Tomography, Optical Coherence Vascular Endothelial Growth Factor A - metabolism
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