Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology

In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenviron...

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Veröffentlicht in:	Circulation research 2016-01, Vol.118 (1), p.95-107
Hauptverfasser:	Hodgkinson, Conrad P, Bareja, Akshay, Gomez, José A, Dzau, Victor J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiology - methods Cardiology - trends Cardiovascular Diseases - diagnosis Cardiovascular Diseases - therapy Cell Differentiation - physiology Humans Myocytes, Cardiac - physiology Myocytes, Cardiac - transplantation Paracrine Communication - physiology Regenerative Medicine - methods Regenerative Medicine - trends Stem Cell Transplantation - methods Stem Cell Transplantation - trends
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container_title	Circulation research
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creator	Hodgkinson, Conrad P Bareja, Akshay Gomez, José A Dzau, Victor J
description	In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
doi_str_mv	10.1161/CIRCRESAHA.115.305373
format	Article
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source	MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete
subjects	Animals Cardiology - methods Cardiology - trends Cardiovascular Diseases - diagnosis Cardiovascular Diseases - therapy Cell Differentiation - physiology Humans Myocytes, Cardiac - physiology Myocytes, Cardiac - transplantation Paracrine Communication - physiology Regenerative Medicine - methods Regenerative Medicine - trends Stem Cell Transplantation - methods Stem Cell Transplantation - trends
title	Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology
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