The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana
Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus Beauveria bassiana , autophagy is associated with fungal growth and development. BbATG1 (a serine/threonine protein kinase) and BbATG8 (a ubiquitin-like protein) have similar roles in autophag...
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| creator | Ying, Sheng-Hua Liu, Jing Chu, Xin-Ling Xie, Xue-Qin Feng, Ming-Guang |
| description | Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus
Beauveria bassiana
, autophagy is associated with fungal growth and development.
BbATG1
(a serine/threonine protein kinase) and
BbATG8
(a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of
BbATG1
and
BbATG8
had impaired conidial germination under starvation stress. The mutant Δ
BbATG8
exhibited enhanced sensitivity to oxidative stress, while a Δ
BbATG1
mutant did not.
BbATG1
and
BbATG8
showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively. A double mutant had a reduction similar to Δ
BbATG1
. Additionally, both
BbATG1
and
BbATG8
affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays and showed a greater reduction in topical infection. However,
BbATG1
and
BbATG8
had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence. |
| doi_str_mv | 10.1038/srep26376 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4873834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4165375061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-6667327271d10f51b467f9f0516920cb5b22edf0278a76d1ad7ff677c7d4ce353</originalsourceid><addsrcrecordid>eNplkc9u1DAQxiMEolXpgRdAlrgAIuA_cZxckNoKClIlLsvZmjjjjausHexkpX0Y3hUvW5YFfLDHMz99M6OvKJ4z-o5R0bxPESdeC1U_Ks45rWTJBeePT-Kz4jKle5qP5G3F2qfFGVesVVI258WP1YAEljlMA6x3ZcQRZuzJGj0mct1drW4ZAd8fwoYMsEXSO2sxop-JXbyZXfCJOP8n7WCfe0vSHDElki-XZvAGfyltXVxG3P-CJZudCRPMQ8gNyTXCssXogHSQkgMPz4onFsaElw_vRfHt08fVzefy7uvtl5uru9JUopnLuq6V4Cpv1TNqJeuqWtnWUsnqllPTyY5z7C3lqgFV9wx6ZW2tlFF9ZVBIcVF8OOhOS7fB3uQlIox6im4DcacDOP13xbtBr8NWV40SjaiywKsHgRi-L5hmvXHJ4DiCx7AkzVRL81Bts0df_oPehyX6vJ5mDZNCKCHbTL0-UCaGlC22x2EY1Xvf9dH3zL44nf5I_nY5A28OQMolv8Z40vI_tZ_ZgLmg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1815337359</pqid></control><display><type>article</type><title>The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana</title><source>SpringerOpen</source><source>Nature (Open Access)</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Ying, Sheng-Hua ; Liu, Jing ; Chu, Xin-Ling ; Xie, Xue-Qin ; Feng, Ming-Guang</creator><creatorcontrib>Ying, Sheng-Hua ; Liu, Jing ; Chu, Xin-Ling ; Xie, Xue-Qin ; Feng, Ming-Guang</creatorcontrib><description>Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus
Beauveria bassiana
, autophagy is associated with fungal growth and development.
BbATG1
(a serine/threonine protein kinase) and
BbATG8
(a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of
BbATG1
and
BbATG8
had impaired conidial germination under starvation stress. The mutant Δ
BbATG8
exhibited enhanced sensitivity to oxidative stress, while a Δ
BbATG1
mutant did not.
BbATG1
and
BbATG8
showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively. A double mutant had a reduction similar to Δ
BbATG1
. Additionally, both
BbATG1
and
BbATG8
affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays and showed a greater reduction in topical infection. However,
BbATG1
and
BbATG8
had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep26376</identifier><identifier>PMID: 27197558</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/19 ; 38/77 ; 42/41 ; 631/326/193/2538 ; 631/326/193/2542 ; 631/326/421 ; Animals ; Autophagy ; Autophagy-Related Protein 8 Family - genetics ; Autophagy-Related Protein 8 Family - metabolism ; Autophagy-Related Protein-1 Homolog - genetics ; Autophagy-Related Protein-1 Homolog - metabolism ; Beauveria - pathogenicity ; Beauveria - physiology ; Beauveria bassiana ; Conidia ; Deficient mutant ; Entomopathogenic fungi ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Germination ; Humanities and Social Sciences ; Insecta - microbiology ; Kinases ; multidisciplinary ; Mutation ; Oxidative stress ; Phagocytosis ; Protein-serine/threonine kinase ; Proteins ; Reproduction, Asexual ; Science ; Spores, Fungal - pathogenicity ; Spores, Fungal - physiology ; Stress, Physiological ; Ubiquitin ; Virulence</subject><ispartof>Scientific reports, 2016-05, Vol.6 (1), p.26376-26376, Article 26376</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group May 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-6667327271d10f51b467f9f0516920cb5b22edf0278a76d1ad7ff677c7d4ce353</citedby><cites>FETCH-LOGICAL-c438t-6667327271d10f51b467f9f0516920cb5b22edf0278a76d1ad7ff677c7d4ce353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873834/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873834/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27197558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ying, Sheng-Hua</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Chu, Xin-Ling</creatorcontrib><creatorcontrib>Xie, Xue-Qin</creatorcontrib><creatorcontrib>Feng, Ming-Guang</creatorcontrib><title>The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus
Beauveria bassiana
, autophagy is associated with fungal growth and development.
BbATG1
(a serine/threonine protein kinase) and
BbATG8
(a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of
BbATG1
and
BbATG8
had impaired conidial germination under starvation stress. The mutant Δ
BbATG8
exhibited enhanced sensitivity to oxidative stress, while a Δ
BbATG1
mutant did not.
BbATG1
and
BbATG8
showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively. A double mutant had a reduction similar to Δ
BbATG1
. Additionally, both
BbATG1
and
BbATG8
affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays and showed a greater reduction in topical infection. However,
BbATG1
and
BbATG8
had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence.</description><subject>14/19</subject><subject>38/77</subject><subject>42/41</subject><subject>631/326/193/2538</subject><subject>631/326/193/2542</subject><subject>631/326/421</subject><subject>Animals</subject><subject>Autophagy</subject><subject>Autophagy-Related Protein 8 Family - genetics</subject><subject>Autophagy-Related Protein 8 Family - metabolism</subject><subject>Autophagy-Related Protein-1 Homolog - genetics</subject><subject>Autophagy-Related Protein-1 Homolog - metabolism</subject><subject>Beauveria - pathogenicity</subject><subject>Beauveria - physiology</subject><subject>Beauveria bassiana</subject><subject>Conidia</subject><subject>Deficient mutant</subject><subject>Entomopathogenic fungi</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - metabolism</subject><subject>Germination</subject><subject>Humanities and Social Sciences</subject><subject>Insecta - microbiology</subject><subject>Kinases</subject><subject>multidisciplinary</subject><subject>Mutation</subject><subject>Oxidative stress</subject><subject>Phagocytosis</subject><subject>Protein-serine/threonine kinase</subject><subject>Proteins</subject><subject>Reproduction, Asexual</subject><subject>Science</subject><subject>Spores, Fungal - pathogenicity</subject><subject>Spores, Fungal - physiology</subject><subject>Stress, Physiological</subject><subject>Ubiquitin</subject><subject>Virulence</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc9u1DAQxiMEolXpgRdAlrgAIuA_cZxckNoKClIlLsvZmjjjjausHexkpX0Y3hUvW5YFfLDHMz99M6OvKJ4z-o5R0bxPESdeC1U_Ks45rWTJBeePT-Kz4jKle5qP5G3F2qfFGVesVVI258WP1YAEljlMA6x3ZcQRZuzJGj0mct1drW4ZAd8fwoYMsEXSO2sxop-JXbyZXfCJOP8n7WCfe0vSHDElki-XZvAGfyltXVxG3P-CJZudCRPMQ8gNyTXCssXogHSQkgMPz4onFsaElw_vRfHt08fVzefy7uvtl5uru9JUopnLuq6V4Cpv1TNqJeuqWtnWUsnqllPTyY5z7C3lqgFV9wx6ZW2tlFF9ZVBIcVF8OOhOS7fB3uQlIox6im4DcacDOP13xbtBr8NWV40SjaiywKsHgRi-L5hmvXHJ4DiCx7AkzVRL81Bts0df_oPehyX6vJ5mDZNCKCHbTL0-UCaGlC22x2EY1Xvf9dH3zL44nf5I_nY5A28OQMolv8Z40vI_tZ_ZgLmg</recordid><startdate>20160520</startdate><enddate>20160520</enddate><creator>Ying, Sheng-Hua</creator><creator>Liu, Jing</creator><creator>Chu, Xin-Ling</creator><creator>Xie, Xue-Qin</creator><creator>Feng, Ming-Guang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160520</creationdate><title>The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana</title><author>Ying, Sheng-Hua ; Liu, Jing ; Chu, Xin-Ling ; Xie, Xue-Qin ; Feng, Ming-Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-6667327271d10f51b467f9f0516920cb5b22edf0278a76d1ad7ff677c7d4ce353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>14/19</topic><topic>38/77</topic><topic>42/41</topic><topic>631/326/193/2538</topic><topic>631/326/193/2542</topic><topic>631/326/421</topic><topic>Animals</topic><topic>Autophagy</topic><topic>Autophagy-Related Protein 8 Family - genetics</topic><topic>Autophagy-Related Protein 8 Family - metabolism</topic><topic>Autophagy-Related Protein-1 Homolog - genetics</topic><topic>Autophagy-Related Protein-1 Homolog - metabolism</topic><topic>Beauveria - pathogenicity</topic><topic>Beauveria - physiology</topic><topic>Beauveria bassiana</topic><topic>Conidia</topic><topic>Deficient mutant</topic><topic>Entomopathogenic fungi</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Germination</topic><topic>Humanities and Social Sciences</topic><topic>Insecta - microbiology</topic><topic>Kinases</topic><topic>multidisciplinary</topic><topic>Mutation</topic><topic>Oxidative stress</topic><topic>Phagocytosis</topic><topic>Protein-serine/threonine kinase</topic><topic>Proteins</topic><topic>Reproduction, Asexual</topic><topic>Science</topic><topic>Spores, Fungal - pathogenicity</topic><topic>Spores, Fungal - physiology</topic><topic>Stress, Physiological</topic><topic>Ubiquitin</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ying, Sheng-Hua</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Chu, Xin-Ling</creatorcontrib><creatorcontrib>Xie, Xue-Qin</creatorcontrib><creatorcontrib>Feng, Ming-Guang</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ying, Sheng-Hua</au><au>Liu, Jing</au><au>Chu, Xin-Ling</au><au>Xie, Xue-Qin</au><au>Feng, Ming-Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-05-20</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>26376</spage><epage>26376</epage><pages>26376-26376</pages><artnum>26376</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus
Beauveria bassiana
, autophagy is associated with fungal growth and development.
BbATG1
(a serine/threonine protein kinase) and
BbATG8
(a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of
BbATG1
and
BbATG8
had impaired conidial germination under starvation stress. The mutant Δ
BbATG8
exhibited enhanced sensitivity to oxidative stress, while a Δ
BbATG1
mutant did not.
BbATG1
and
BbATG8
showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in Δ
BbATG1
and Δ
BbATG8
mutants, respectively. A double mutant had a reduction similar to Δ
BbATG1
. Additionally, both
BbATG1
and
BbATG8
affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays and showed a greater reduction in topical infection. However,
BbATG1
and
BbATG8
had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27197558</pmid><doi>10.1038/srep26376</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2016-05, Vol.6 (1), p.26376-26376, Article 26376 |
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| source | SpringerOpen; Nature (Open Access); MEDLINE; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | 14/19 38/77 42/41 631/326/193/2538 631/326/193/2542 631/326/421 Animals Autophagy Autophagy-Related Protein 8 Family - genetics Autophagy-Related Protein 8 Family - metabolism Autophagy-Related Protein-1 Homolog - genetics Autophagy-Related Protein-1 Homolog - metabolism Beauveria - pathogenicity Beauveria - physiology Beauveria bassiana Conidia Deficient mutant Entomopathogenic fungi Fungal Proteins - genetics Fungal Proteins - metabolism Germination Humanities and Social Sciences Insecta - microbiology Kinases multidisciplinary Mutation Oxidative stress Phagocytosis Protein-serine/threonine kinase Proteins Reproduction, Asexual Science Spores, Fungal - pathogenicity Spores, Fungal - physiology Stress, Physiological Ubiquitin Virulence |
| title | The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana |
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