Effects of cyclopiazonic acid and dexamethasone on serotonin-induced calcium responses in vascular smooth muscle cells

We previously observed that sarcoendoplasmic reticulum Ca 2+ ATPase (SERCA) blockade by cyclopiazonic acid (CPA) significantly potentiates serotonin (5-hydroxytryptamine (5-HT))-induced vascular contractions. Furthermore, 5-HT receptor antagonist methysergide partially inhibited CPA-potentiated 5-HT...

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Veröffentlicht in:	Journal of physiology and biochemistry 2016-06, Vol.72 (2), p.245-253
Hauptverfasser:	Selli, Cigdem, Tosun, Metiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Physiology Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biomedical and Life Sciences Biomedicine Calcium Channel Blockers - pharmacology Calcium Signaling - drug effects Cell Line Dexamethasone - antagonists & inhibitors Dexamethasone - pharmacology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Human Physiology Indoles - antagonists & inhibitors Indoles - pharmacology Ketanserin - pharmacology Methysergide - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase Inhibitors - pharmacology Rats Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Serotonin - chemistry Serotonin - metabolism Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - chemistry Serotonin Receptor Agonists - pharmacology Vasoconstrictor Agents - antagonists & inhibitors Vasoconstrictor Agents - pharmacology Vasodilator Agents - antagonists & inhibitors Vasodilator Agents - pharmacology
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