CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

Current therapies for high-grade gliomas extend survival only modestly. The glioma microenvironment, including glioma-associated microglia/macrophages (GAM), is a potential therapeutic target. The microglia/macrophage cytokine CSF1 and its receptor CSF1R are overexpressed in human high-grade gliomas...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-05, Vol.76 (9), p.2552-2560
Hauptverfasser:	De, Ishani, Steffen, Megan D, Clark, Paul A, Patros, Clayton J, Sokn, Emily, Bishop, Stephanie M, Litscher, Suzanne, Maklakova, Vilena I, Kuo, John S, Rodriguez, Fausto J, Collier, Lara S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - pathology Cell Line, Tumor Glioma - pathology Humans Immunohistochemistry Macrophage Colony-Stimulating Factor - biosynthesis Macrophages - cytology Mice Mice, Transgenic Microglia - cytology Microscopy, Confocal Polymerase Chain Reaction Receptor, Macrophage Colony-Stimulating Factor - metabolism Tissue Array Analysis Up-Regulation
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