DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

A wide range of human malignancies displays aberrant activation of Hedgehog (HH)/GLI signaling, including cancers of the skin, brain, gastrointestinal tract and hematopoietic system. Targeting oncogenic HH/GLI signaling with small molecule inhibitors of the essential pathway effector Smoothened (SMO...

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Veröffentlicht in:	Oncotarget 2016-02, Vol.7 (6), p.7134-7148
Hauptverfasser:	Gruber, Wolfgang, Hutzinger, Martin, Elmer, Dominik Patrick, Parigger, Thomas, Sternberg, Christina, Cegielkowski, Lukasz, Zaja, Mirko, Leban, Johann, Michel, Susanne, Hamm, Svetlana, Vitt, Daniel, Aberger, Fritz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Blotting, Western Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell Proliferation - drug effects Cells, Cultured Drug Resistance, Neoplasm Dyrk Kinases Forkhead Transcription Factors - physiology Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Mice Mice, Nude NIH 3T3 Cells Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Smoothened Receptor - antagonists & inhibitors Smoothened Receptor - genetics Smoothened Receptor - metabolism Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 - antagonists & inhibitors Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism
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