Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues

Survivin overexpression is associated with poor prognosis of human gastric cancer, and is a target for gastric cancer therapy. YM155 is originally identified as a specific inhibitor of survivin. In this study, we investigated the antitumor effect of YM155 on human gastric cancer. Our results showed...

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Veröffentlicht in:	Oncotarget 2016-02, Vol.7 (6), p.7096-7109
Hauptverfasser:	Cheng, Xiao Jiao, Lin, Jia Cheng, Ding, Yan Fei, Zhu, Liming, Ye, Jing, Tu, Shui Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western Cell Proliferation - drug effects Female Humans Imidazoles - pharmacology Immunoenzyme Techniques Inhibitor of Apoptosis Proteins - antagonists & inhibitors Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude Naphthoquinones - pharmacology Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach - metabolism Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - prevention & control Tumor Cells, Cultured Xenograft Model Antitumor Assays
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