Sp-1 and c-Myc Mediate Lysophosphatidic Acid–Induced Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Cells via a Hypoxia-Inducible Factor-1–Independent Mechanism

Purpose: Lysophosphatidic acid (LPA), which is present in ascites of ovarian cancer patients, stimulates expression of vascular endothelial growth factor (VEGF). VEGF is essential for the development and abdominal dissemination of ovarian cancer. We examined how LPA drives VEGF expression to gain a...

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Veröffentlicht in:	Clinical cancer research 2009-01, Vol.15 (2), p.492-501
Hauptverfasser:	YUANDA SONG, JINHUA WU, OYESANYA, Regina A, LEE, Zendra, MUKHERJEE, Abir, XIANJUN FANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences c-Myc Cell Line, Tumor Female Female genital diseases Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics HIF Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis lysophosphatidic acid Lysophospholipids - metabolism Medical sciences Models, Biological Neovascularization, Pathologic Ovarian Neoplasms - metabolism Pharmacology. Drug treatments Phosphorylation Promoter Regions, Genetic Proto-Oncogene Proteins c-myc - metabolism RNA, Small Interfering - metabolism Sp-1 Sp1 Transcription Factor - physiology Tumors vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - chemistry
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