MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

Summary Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chain‐relat...

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Veröffentlicht in:	Clinical and experimental immunology 2016-06, Vol.184 (3), p.323-331
Hauptverfasser:	Martinez‐Chamorro, A., Moreno, A., Gómez‐García, M., Cabello, M. J., Martin, J., Lopez‐Nevot, M. Á.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess - diagnosis Abscess - genetics Abscess - immunology Abscess - pathology Adult Age of Onset Alleles Amino Acid Sequence autoimmunity Case-Control Studies cell surface molecules Colitis, Ulcerative - diagnosis Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - pathology Female Gene Expression Gene Frequency Genetic Predisposition to Disease Haplotypes Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA-B27 Antigen - genetics HLA-B27 Antigen - immunology HLA-B52 Antigen - genetics HLA-B52 Antigen - immunology Humans inflammation Male MHC Middle Aged Models, Molecular molecular biology Odds Ratio Original Polymorphism, Genetic - immunology Protein Domains Protein Isoforms - genetics Protein Isoforms - immunology Sequence Alignment
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