An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia
In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help f...
Gespeichert in:
Veröffentlicht in: | Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-12 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 12 |
---|---|
container_issue | 2016 |
container_start_page | 1 |
container_title | Oxidative medicine and cellular longevity |
container_volume | 2016 |
creator | Yang, Hongjun Zhan, Hao Fang, Jing Liu, Xin Tang, Liying Liu, Mengting Wu, Hongwei |
description | In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers. |
doi_str_mv | 10.1155/2016/9162074 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4871976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4056693381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-af52df3a1d120033b45991bc40d6f7cd6dc6ca8261dc46916ff429eeeae727983</originalsourceid><addsrcrecordid>eNqNkc1PHCEYxompUWu9eW4m8dLEjgLDwHBpohvbmtg2aeqZMPDiorOgMLub_vdls9vVeurp_eCXJ-_Dg9AxwWeEtO05xYSfS8IpFmwHHRDJaI2lZG-2Pcb76G3O9xjzhjKyh_apoIKJDh8gcxGqq4W3EAzUlzqDrX7CwsOyiq50gx7L5huMuo-DHyFXOjzPpvoO4zKmh0Jm0MlMqxiqCSTokx6q62ymMPP6Hdp1eshwtKmH6Pbz1a_J1_rmx5frycVNbZggY61dS61rNLGEYtw0PWulJL1h2HInjOXWcKM7yok1jBfHzjEqAUBDsSO75hB9Wus-zvsZWANhLGeox-RnOv1WUXv170vwU3UXF4p1gkjBi8CHjUCKT3PIo5r5bGAYdIA4z4oI2XaCSsoKevIKvY_zFIq9QnWd7FrOVtTHNWVSzDmB2x5DsFqlp1bpqU16BX__0sAW_htXAU7XwNQHq5f-P-WgMOD0M01I-fG2-QORzKv7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1788985644</pqid></control><display><type>article</type><title>An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yang, Hongjun ; Zhan, Hao ; Fang, Jing ; Liu, Xin ; Tang, Liying ; Liu, Mengting ; Wu, Hongwei</creator><contributor>Miyamoto, Sayuri</contributor><creatorcontrib>Yang, Hongjun ; Zhan, Hao ; Fang, Jing ; Liu, Xin ; Tang, Liying ; Liu, Mengting ; Wu, Hongwei ; Miyamoto, Sayuri</creatorcontrib><description>In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2016/9162074</identifier><identifier>PMID: 27274780</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Amino Acids - metabolism ; Animals ; Biomarkers ; Biomarkers - metabolism ; Brain Ischemia - metabolism ; Brain Ischemia - pathology ; Brain research ; Chromatography ; Databases, Factual ; Disease Models, Animal ; Fluids ; Hogs ; Ischemia ; Metabolic Networks and Pathways - physiology ; Metabolism ; Metabolites ; Metabolomics ; Neurotransmitter Agents - metabolism ; NMR ; Nuclear magnetic resonance ; Nucleic Acids - metabolism ; Pathogenesis ; Review ; Signal transduction ; Studies ; Urine</subject><ispartof>Oxidative medicine and cellular longevity, 2016-01, Vol.2016 (2016), p.1-12</ispartof><rights>Copyright © 2016 Mengting Liu et al.</rights><rights>Copyright © 2016 Mengting Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Mengting Liu et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-af52df3a1d120033b45991bc40d6f7cd6dc6ca8261dc46916ff429eeeae727983</citedby><cites>FETCH-LOGICAL-c471t-af52df3a1d120033b45991bc40d6f7cd6dc6ca8261dc46916ff429eeeae727983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871976/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871976/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27274780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Miyamoto, Sayuri</contributor><creatorcontrib>Yang, Hongjun</creatorcontrib><creatorcontrib>Zhan, Hao</creatorcontrib><creatorcontrib>Fang, Jing</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Tang, Liying</creatorcontrib><creatorcontrib>Liu, Mengting</creatorcontrib><creatorcontrib>Wu, Hongwei</creatorcontrib><title>An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers.</description><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - pathology</subject><subject>Brain research</subject><subject>Chromatography</subject><subject>Databases, Factual</subject><subject>Disease Models, Animal</subject><subject>Fluids</subject><subject>Hogs</subject><subject>Ischemia</subject><subject>Metabolic Networks and Pathways - physiology</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nucleic Acids - metabolism</subject><subject>Pathogenesis</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Studies</subject><subject>Urine</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1PHCEYxompUWu9eW4m8dLEjgLDwHBpohvbmtg2aeqZMPDiorOgMLub_vdls9vVeurp_eCXJ-_Dg9AxwWeEtO05xYSfS8IpFmwHHRDJaI2lZG-2Pcb76G3O9xjzhjKyh_apoIKJDh8gcxGqq4W3EAzUlzqDrX7CwsOyiq50gx7L5huMuo-DHyFXOjzPpvoO4zKmh0Jm0MlMqxiqCSTokx6q62ymMPP6Hdp1eshwtKmH6Pbz1a_J1_rmx5frycVNbZggY61dS61rNLGEYtw0PWulJL1h2HInjOXWcKM7yok1jBfHzjEqAUBDsSO75hB9Wus-zvsZWANhLGeox-RnOv1WUXv170vwU3UXF4p1gkjBi8CHjUCKT3PIo5r5bGAYdIA4z4oI2XaCSsoKevIKvY_zFIq9QnWd7FrOVtTHNWVSzDmB2x5DsFqlp1bpqU16BX__0sAW_htXAU7XwNQHq5f-P-WgMOD0M01I-fG2-QORzKv7</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Yang, Hongjun</creator><creator>Zhan, Hao</creator><creator>Fang, Jing</creator><creator>Liu, Xin</creator><creator>Tang, Liying</creator><creator>Liu, Mengting</creator><creator>Wu, Hongwei</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia</title><author>Yang, Hongjun ; Zhan, Hao ; Fang, Jing ; Liu, Xin ; Tang, Liying ; Liu, Mengting ; Wu, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-af52df3a1d120033b45991bc40d6f7cd6dc6ca8261dc46916ff429eeeae727983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - pathology</topic><topic>Brain research</topic><topic>Chromatography</topic><topic>Databases, Factual</topic><topic>Disease Models, Animal</topic><topic>Fluids</topic><topic>Hogs</topic><topic>Ischemia</topic><topic>Metabolic Networks and Pathways - physiology</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nucleic Acids - metabolism</topic><topic>Pathogenesis</topic><topic>Review</topic><topic>Signal transduction</topic><topic>Studies</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hongjun</creatorcontrib><creatorcontrib>Zhan, Hao</creatorcontrib><creatorcontrib>Fang, Jing</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Tang, Liying</creatorcontrib><creatorcontrib>Liu, Mengting</creatorcontrib><creatorcontrib>Wu, Hongwei</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hongjun</au><au>Zhan, Hao</au><au>Fang, Jing</au><au>Liu, Xin</au><au>Tang, Liying</au><au>Liu, Mengting</au><au>Wu, Hongwei</au><au>Miyamoto, Sayuri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27274780</pmid><doi>10.1155/2016/9162074</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1942-0900 |
ispartof | Oxidative medicine and cellular longevity, 2016-01, Vol.2016 (2016), p.1-12 |
issn | 1942-0900 1942-0994 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4871976 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
subjects | Amino Acids - metabolism Animals Biomarkers Biomarkers - metabolism Brain Ischemia - metabolism Brain Ischemia - pathology Brain research Chromatography Databases, Factual Disease Models, Animal Fluids Hogs Ischemia Metabolic Networks and Pathways - physiology Metabolism Metabolites Metabolomics Neurotransmitter Agents - metabolism NMR Nuclear magnetic resonance Nucleic Acids - metabolism Pathogenesis Review Signal transduction Studies Urine |
title | An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T15%3A37%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Evidence-Based%20Review%20of%20Related%20Metabolites%20and%20Metabolic%20Network%20Research%20on%20Cerebral%20Ischemia&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Yang,%20Hongjun&rft.date=2016-01-01&rft.volume=2016&rft.issue=2016&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2016/9162074&rft_dat=%3Cproquest_pubme%3E4056693381%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1788985644&rft_id=info:pmid/27274780&rfr_iscdi=true |