An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia

In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help f...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-12
Hauptverfasser: Yang, Hongjun, Zhan, Hao, Fang, Jing, Liu, Xin, Tang, Liying, Liu, Mengting, Wu, Hongwei
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container_end_page 12
container_issue 2016
container_start_page 1
container_title Oxidative medicine and cellular longevity
container_volume 2016
creator Yang, Hongjun
Zhan, Hao
Fang, Jing
Liu, Xin
Tang, Liying
Liu, Mengting
Wu, Hongwei
description In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers.
doi_str_mv 10.1155/2016/9162074
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection
subjects Amino Acids - metabolism
Animals
Biomarkers
Biomarkers - metabolism
Brain Ischemia - metabolism
Brain Ischemia - pathology
Brain research
Chromatography
Databases, Factual
Disease Models, Animal
Fluids
Hogs
Ischemia
Metabolic Networks and Pathways - physiology
Metabolism
Metabolites
Metabolomics
Neurotransmitter Agents - metabolism
NMR
Nuclear magnetic resonance
Nucleic Acids - metabolism
Pathogenesis
Review
Signal transduction
Studies
Urine
title An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia
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