Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine

Twenty‐five years ago a “new” protein was identified from cancers that caused hypercalcemia. It was credited for its ability to mimic parathyroid hormone (PTH), and hence was termed parathyroid hormone‐related protein (PTHrP). Today it is recognized for its widespread distribution, its endocrine, pa...

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Veröffentlicht in:	Journal of bone and mineral research 2012-06, Vol.27 (6), p.1231-1239
Hauptverfasser:	McCauley, Laurie K, Martin, T John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences BONE Calcium homeostasis CARTILAGE Cytokines - metabolism Evolution, Molecular Fundamental and applied biological sciences. Psychology History, 20th Century Humans HYPERCALCEMIA Neoplasms - metabolism Organ Specificity PARACRINE Parathyroid Hormone-Related Protein - history Parathyroid Hormone-Related Protein - metabolism PTH PTHrP Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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