The role of epigenetics in idiopathic male infertility
Infertility is a complex disorder with multiple genetic and environmental causes. Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2016-05, Vol.33 (5), p.553-569 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Gunes, Sezgin Arslan, Mehmet Alper Hekim, Gulgez Neslihan Taskurt Asci, Ramazan |
| description | Infertility is a complex disorder with multiple genetic and environmental causes. Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. Many studies have indicated that epigenetic modifications, including DNA methylation in imprinted and developmental genes, histone tail modifications and short non-coding RNAs in spermatozoa may have a role in idiopathic male infertility. |
| doi_str_mv | 10.1007/s10815-016-0682-8 |
| format | Article |
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Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. 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Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. 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| subjects | Acetylation DNA Methylation Epigenesis, Genetic - physiology Epigenetics Genomic Imprinting Gynecology Histones - metabolism Human Genetics Humans Infertility, Male - genetics Male Medicine Medicine & Public Health MicroRNAs - physiology Protamines - metabolism Reproductive Medicine Review Spermatozoa - metabolism Testis - metabolism |
| title | The role of epigenetics in idiopathic male infertility |
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