Antagonism of the Thromboxane-Prostanoid Receptor is Cardioprotective against Right Ventricular Pressure Overload

Right ventricular (RV) failure is the primary cause of death in pulmonary arterial hypertension (PAH) and is a significant cause of morbidity and mortality in other forms of pulmonary hypertension. There are no approved therapies directed at preserving RV function. F-series and E-series isoprostanes...

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Veröffentlicht in:	Pulmonary circulation 2016-06, Vol.6 (2), p.211-223
Hauptverfasser:	West, James D., Voss, Bryan M., Pavliv, Leo, de Caestecker, Mark, Hemnes, Anna R., Carrier, Erica J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptation cardiomyocyte Gene expression isoprostane Original Research pulmonary arterial hypertension Pulmonary arteries Pulmonary hypertension right ventricle thromboxane‐prostanoid receptor
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