Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse

Depression is a common mental illness and a leading cause of disability. The most widely prescribed antidepressant medications are serotonin (5-HT) selective reuptake inhibitors (SSRIs). Although there is much support for 5-HT transporter (SERT) antagonism as a basis of antidepressant efficacy, this...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2016-06, Vol.41 (7), p.1733-1741
Hauptverfasser:	Nackenoff, Alex G, Moussa-Tooks, Alexandra B, McMeekin, Austin M, Veenstra-VanderWeele, Jeremy, Blakely, Randy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - pharmacology Brain - drug effects Brain - metabolism Brain - ultrastructure Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Citalopram - pharmacology Depression - drug therapy Depression - genetics Depression - metabolism Disease Models, Animal Fluoxetine - pharmacology Food Preferences - drug effects Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hindlimb Suspension Hippocampus - drug effects Male Mental depression Methionine - genetics Mice Mice, Inbred C57BL Mice, Transgenic Mutagenesis Original Serotonin Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Synaptosomes - metabolism
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