Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis

During visceral leishmaniasis (VL), Th1-based inflammation is induced to control intracellular parasites. Inflammation-based pathology was shown to be dampened by IL-10 and eventual programmed death 1-mediated T cell exhaustion. Cell type(s) responsible for the initiation of T cell-produced IL-10 du...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-05, Vol.196 (10), p.4100-4109
Hauptverfasser:	Schaut, Robert G, Lamb, Ian M, Toepp, Angela J, Scott, Benjamin, Mendes-Aguiar, Carolina O, Coutinho, Jose F V, Jeronimo, Selma M B, Wilson, Mary E, Harty, John T, Waldschmidt, Thomas J, Petersen, Christine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Blocking - metabolism Antibodies, Protozoan - metabolism Antigens, Protozoan - immunology B-Lymphocytes, Regulatory - immunology B-Lymphocytes, Regulatory - parasitology B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Cells, Cultured Disease Progression Dogs Female Humans Immune Tolerance Immunoglobulin D - metabolism Interleukin-10 - metabolism Leishmania infantum - immunology Leishmaniasis, Visceral - immunology Male Protozoan Proteins - immunology Th1 Cells - immunology Th1 Cells - parasitology
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