α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors

In the brain, AMPA-type glutamate receptors are major postsynaptic receptors at excitatory synapses that mediate fast neurotransmission and synaptic plasticity. α/β-Hydrolase domain-containing 6 (ABHD6), a monoacylglycerol lipase, was previously found to be a component of AMPA receptor macromolecula...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-05, Vol.113 (19), p.E2695-E2704
Hauptverfasser:	Wei, Mengping, Zhang, Jian, Jia, Moye, Yang, Chaojuan, Pan, Yunlong, Li, Shuaiqi, Luo, Yiwen, Zheng, Junyuan, Ji, Jianguo, Chen, Jianguo, Hu, Xinli, Xiong, Jingwei, Shi, Yun, Zhang, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Biological Sciences Cell Membrane - metabolism Cells, Cultured HEK293 Cells Hippocampus - cytology Hippocampus - physiology Humans Mice Monoacylglycerol Lipases - metabolism Neurons - physiology PNAS Plus Protein Domains - physiology Receptors, AMPA - metabolism Synaptic Transmission - physiology
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