Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE‑1 Inhibitors

An ecofriendly synthetic pathway for the synthesis of donepezil precursors is described. Alternative energy sources were used for the total synthesis in order to improve yields, regioselectively, and rate of each synthetic step and to reduce the coproduction of waste at the same time. For all produc...

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Veröffentlicht in:	ACS medicinal chemistry letters 2016-05, Vol.7 (5), p.470-475
Hauptverfasser:	Costanzo, Paola, Cariati, Luca, Desiderio, Doriana, Sgammato, Roberta, Lamberti, Anna, Arcone, Rosaria, Salerno, Raffaele, Nardi, Monica, Masullo, Mariorosario, Oliverio, Manuela
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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