Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions
Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions a...
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| Veröffentlicht in: | Scientific reports 2016-05, Vol.6 (1), p.25920-25920, Article 25920 |
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| creator | Samalin, Ludovic Vieta, Eduard Okasha, Tarek Ahmed Uddin, MM. Jalal Ahmadi Abhari, Seyed Ali Nacef, Fethi Mishyiev, Vyacheslav Aizenberg, Dovi Ratner, Yaël Melas-Melt, Lydie Sedeki, Idir Llorca, Pierre Michel |
| description | Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions across various intercontinental countries (Bangladesh, Egypt, Iran, Israel, Tunisia, and Ukraine). Data on socio-demographic and disease characteristics, current symptomatology, and pharmacological treatment were collected. Comparisons between groups were performed using standard statistical tests. Overall, 1180 patients were included. The median time from initial diagnosis was 80 months. Major depressive disorder was the most common initial diagnosis. Mood stabilizers and antipsychotics were the most common drugs being prescribed at the time of the study. Antidepressants (mainly selective serotonin uptake inhibitors [SSRIs]) were administered to 36.1% of patients. Patients with bipolar I disorder received higher number of antipsychotics and anxiolytics than those with bipolar II disorder (p |
| doi_str_mv | 10.1038/srep25920 |
| format | Article |
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Jalal ; Ahmadi Abhari, Seyed Ali ; Nacef, Fethi ; Mishyiev, Vyacheslav ; Aizenberg, Dovi ; Ratner, Yaël ; Melas-Melt, Lydie ; Sedeki, Idir ; Llorca, Pierre Michel</creator><creatorcontrib>Samalin, Ludovic ; Vieta, Eduard ; Okasha, Tarek Ahmed ; Uddin, MM. Jalal ; Ahmadi Abhari, Seyed Ali ; Nacef, Fethi ; Mishyiev, Vyacheslav ; Aizenberg, Dovi ; Ratner, Yaël ; Melas-Melt, Lydie ; Sedeki, Idir ; Llorca, Pierre Michel</creatorcontrib><description>Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions across various intercontinental countries (Bangladesh, Egypt, Iran, Israel, Tunisia, and Ukraine). Data on socio-demographic and disease characteristics, current symptomatology, and pharmacological treatment were collected. Comparisons between groups were performed using standard statistical tests. Overall, 1180 patients were included. The median time from initial diagnosis was 80 months. Major depressive disorder was the most common initial diagnosis. Mood stabilizers and antipsychotics were the most common drugs being prescribed at the time of the study. Antidepressants (mainly selective serotonin uptake inhibitors [SSRIs]) were administered to 36.1% of patients. Patients with bipolar I disorder received higher number of antipsychotics and anxiolytics than those with bipolar II disorder (p < 0.001). Presence of depressive symptoms was associated with an increase in antidepressant use (p < 0.001). Bipolar disorder real-life management practice, irrespective of region, shows a delay in diagnosis and an overuse of antidepressants. Clinical decision-making appears to be based on a multidimensional approach related to current symptomatology and type of bipolar disorder.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep25920</identifier><identifier>PMID: 27181262</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1807 ; 692/700/565/1436 ; Clinical neuropsychology ; Cognitive science ; Cognitive Sciences ; Humanities and Social Sciences ; Life Sciences ; Manic-depressive illness ; multidisciplinary ; Neurobiology ; Neurons and Cognition ; Neuropsicologia clínica ; Neuroscience ; Psychology and behavior ; Science ; Science (multidisciplinary) ; Trastorn bipolar</subject><ispartof>Scientific reports, 2016-05, Vol.6 (1), p.25920-25920, Article 25920</ispartof><rights>The Author(s) 2016</rights><rights>cc-by (c) Samalin, Ludovic et al., 2016 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-b0528ebcf9b57b14118633c718a1ee5966ce42844927005629990655badeda213</citedby><cites>FETCH-LOGICAL-c486t-b0528ebcf9b57b14118633c718a1ee5966ce42844927005629990655badeda213</cites><orcidid>0000-0001-7438-8990</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867470/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867470/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,26956,27906,27907,41102,42171,51558,53773,53775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27181262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://uca.hal.science/hal-02174732$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Samalin, Ludovic</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Okasha, Tarek Ahmed</creatorcontrib><creatorcontrib>Uddin, MM. Jalal</creatorcontrib><creatorcontrib>Ahmadi Abhari, Seyed Ali</creatorcontrib><creatorcontrib>Nacef, Fethi</creatorcontrib><creatorcontrib>Mishyiev, Vyacheslav</creatorcontrib><creatorcontrib>Aizenberg, Dovi</creatorcontrib><creatorcontrib>Ratner, Yaël</creatorcontrib><creatorcontrib>Melas-Melt, Lydie</creatorcontrib><creatorcontrib>Sedeki, Idir</creatorcontrib><creatorcontrib>Llorca, Pierre Michel</creatorcontrib><title>Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions across various intercontinental countries (Bangladesh, Egypt, Iran, Israel, Tunisia, and Ukraine). Data on socio-demographic and disease characteristics, current symptomatology, and pharmacological treatment were collected. Comparisons between groups were performed using standard statistical tests. Overall, 1180 patients were included. The median time from initial diagnosis was 80 months. Major depressive disorder was the most common initial diagnosis. Mood stabilizers and antipsychotics were the most common drugs being prescribed at the time of the study. Antidepressants (mainly selective serotonin uptake inhibitors [SSRIs]) were administered to 36.1% of patients. Patients with bipolar I disorder received higher number of antipsychotics and anxiolytics than those with bipolar II disorder (p < 0.001). Presence of depressive symptoms was associated with an increase in antidepressant use (p < 0.001). Bipolar disorder real-life management practice, irrespective of region, shows a delay in diagnosis and an overuse of antidepressants. Clinical decision-making appears to be based on a multidimensional approach related to current symptomatology and type of bipolar disorder.</description><subject>692/1807</subject><subject>692/700/565/1436</subject><subject>Clinical neuropsychology</subject><subject>Cognitive science</subject><subject>Cognitive Sciences</subject><subject>Humanities and Social Sciences</subject><subject>Life Sciences</subject><subject>Manic-depressive illness</subject><subject>multidisciplinary</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Neuropsicologia clínica</subject><subject>Neuroscience</subject><subject>Psychology and behavior</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Trastorn bipolar</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>XX2</sourceid><recordid>eNptks1u1DAQxyNERavSAy-AfATUgD35NAekqgJaaREXOFuOM9l15diL7azUp-FVcTbLtqAmihzP_-f58mTZK0bfM1q0H4LHLVQc6LPsDGhZ5VAAPH_0f5pdhHBH01MBLxl_kZ1Cw1oGNZxlv79JK9c4oo3EDaTTW2ekJ70OzvfoibYkbjAtEb1yNmqbSGmIx7V29iORdtGsjGkvzSUZJxO1wtl4Sayz-V7fJcMBUN6FkAdUi4GEOPX3cyCP0uRGD0hSpF7PcniZnQzSBLw4rOfZzy-ff1zf5KvvX2-vr1a5Kts65l2qrcVODbyrmo6VjLV1UahUpmSIFa9rhSW0ZcmhSX2ogXNO66rqZI-9BFacZ58Wv9upG7Gf8_fSiK3Xo_T3wkkt_lWs3oi124kUvikbmhy8XRxs_jt2c7USs40CS2ABuzkYW1gVJiU8qtRbGff0cTN_QBsQwAuo2nTmzSFB735NGKIYdVBojLTopiBY0_IyvQU8pLLvtMfhmA-jYp4ZcZyZxL5-XPeR_DshCXi3ACFJdo1e3LkpXbcJT3j7A1rRzl4</recordid><startdate>20160516</startdate><enddate>20160516</enddate><creator>Samalin, Ludovic</creator><creator>Vieta, Eduard</creator><creator>Okasha, Tarek Ahmed</creator><creator>Uddin, MM. 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Jalal ; Ahmadi Abhari, Seyed Ali ; Nacef, Fethi ; Mishyiev, Vyacheslav ; Aizenberg, Dovi ; Ratner, Yaël ; Melas-Melt, Lydie ; Sedeki, Idir ; Llorca, Pierre Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-b0528ebcf9b57b14118633c718a1ee5966ce42844927005629990655badeda213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/1807</topic><topic>692/700/565/1436</topic><topic>Clinical neuropsychology</topic><topic>Cognitive science</topic><topic>Cognitive Sciences</topic><topic>Humanities and Social Sciences</topic><topic>Life Sciences</topic><topic>Manic-depressive illness</topic><topic>multidisciplinary</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Neuropsicologia clínica</topic><topic>Neuroscience</topic><topic>Psychology and behavior</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Trastorn bipolar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samalin, Ludovic</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Okasha, Tarek Ahmed</creatorcontrib><creatorcontrib>Uddin, MM. 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Jalal</au><au>Ahmadi Abhari, Seyed Ali</au><au>Nacef, Fethi</au><au>Mishyiev, Vyacheslav</au><au>Aizenberg, Dovi</au><au>Ratner, Yaël</au><au>Melas-Melt, Lydie</au><au>Sedeki, Idir</au><au>Llorca, Pierre Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-05-16</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>25920</spage><epage>25920</epage><pages>25920-25920</pages><artnum>25920</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). 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Presence of depressive symptoms was associated with an increase in antidepressant use (p < 0.001). Bipolar disorder real-life management practice, irrespective of region, shows a delay in diagnosis and an overuse of antidepressants. Clinical decision-making appears to be based on a multidimensional approach related to current symptomatology and type of bipolar disorder.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27181262</pmid><doi>10.1038/srep25920</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7438-8990</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/1807 692/700/565/1436 Clinical neuropsychology Cognitive science Cognitive Sciences Humanities and Social Sciences Life Sciences Manic-depressive illness multidisciplinary Neurobiology Neurons and Cognition Neuropsicologia clínica Neuroscience Psychology and behavior Science Science (multidisciplinary) Trastorn bipolar |
| title | Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions |
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