Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping
Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the subst...
Gespeichert in:
| Veröffentlicht in: | American journal of neuroradiology : AJNR 2016-05, Vol.37 (5), p.782-788 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 788 |
|---|---|
| container_issue | 5 |
| container_start_page | 782 |
| container_title | American journal of neuroradiology : AJNR |
| container_volume | 37 |
| creator | Azuma, M Hirai, T Yamada, K Yamashita, S Ando, Y Tateishi, M Iryo, Y Yoneda, T Kitajima, M Wang, Y Yamashita, Y |
| description | Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease. |
| doi_str_mv | 10.3174/ajnr.A4645 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4867267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1789039340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-6f25c0d077c02d4ef2eb0ed54a663f725bd85afd8b0d87caf970e90789d1b4bb3</originalsourceid><addsrcrecordid>eNpVUU1v1DAQtRCILoULPwD5iJBSHCex4wvSqoVSacuHChI3y47Huy6Jk9pOq_1H_EwctlRwGc943nvj8UPoZUlOqpLXb9W1DyfrmtXNI7QqRcUK0Ygfj9GKlKIpWEnaI_QsxmtCSCM4fYqOKGsp5bRdoV8blSCoHq_jfhgghT1W3uCrSSWXb8-ctRDAd4BHiy_C6PEZTGN0yeXUeZx2gK9mHZPymYA_uW1QC_RL5oNPEd-5tMtV-Ol8XNgugoqAL3OcA5hD_-u80FPm3C5ysYMpOe16l_b4Uk2T89vn6IlVfYQX9-cx-v7h_bfTj8Xm8_nF6XpTdHUpUsEsbTpiCOcdoaYGS0ETME2tGKssp402baOsaTUxLe-UFZyAILwVptS11tUxenfQnWY9gOnyEvl75BTcoMJejsrJ_zve7eR2vJV1yzhlPAu8vhcI480MMcnB5YX6XnkY5yjLPItUoqpJhr45QLswxhjAPowpiVyslYu18o-1Gfzq34c9QP96Wf0GSW6l6Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1789039340</pqid></control><display><type>article</type><title>Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Azuma, M ; Hirai, T ; Yamada, K ; Yamashita, S ; Ando, Y ; Tateishi, M ; Iryo, Y ; Yoneda, T ; Kitajima, M ; Wang, Y ; Yamashita, Y</creator><creatorcontrib>Azuma, M ; Hirai, T ; Yamada, K ; Yamashita, S ; Ando, Y ; Tateishi, M ; Iryo, Y ; Yoneda, T ; Kitajima, M ; Wang, Y ; Yamashita, Y</creatorcontrib><description>Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A4645</identifier><identifier>PMID: 26822728</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Adult Brain ; Aged ; Editor's Choice ; Female ; Gray Matter - diagnostic imaging ; Humans ; Imaging, Three-Dimensional - methods ; Iron - analysis ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Parkinson Disease - diagnostic imaging ; ROC Curve ; Substantia Nigra - chemistry ; Substantia Nigra - diagnostic imaging</subject><ispartof>American journal of neuroradiology : AJNR, 2016-05, Vol.37 (5), p.782-788</ispartof><rights>2016 by American Journal of Neuroradiology.</rights><rights>2016 by American Journal of Neuroradiology 2016 American Journal of Neuroradiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-6f25c0d077c02d4ef2eb0ed54a663f725bd85afd8b0d87caf970e90789d1b4bb3</citedby><cites>FETCH-LOGICAL-c419t-6f25c0d077c02d4ef2eb0ed54a663f725bd85afd8b0d87caf970e90789d1b4bb3</cites><orcidid>0000-0003-1480-2197 ; 0000-0001-7115-9105 ; 0000-0002-9586-8341 ; 0000-0003-1404-8526 ; 0000-0002-2905-1093 ; 0000-0002-4837-4197 ; 0000-0001-0311-5466 ; 0000-0001-9315-3492 ; 0000-0001-9488-8781 ; 0000-0002-6869-3638 ; 0000-0002-7941-637X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867267/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867267/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26822728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azuma, M</creatorcontrib><creatorcontrib>Hirai, T</creatorcontrib><creatorcontrib>Yamada, K</creatorcontrib><creatorcontrib>Yamashita, S</creatorcontrib><creatorcontrib>Ando, Y</creatorcontrib><creatorcontrib>Tateishi, M</creatorcontrib><creatorcontrib>Iryo, Y</creatorcontrib><creatorcontrib>Yoneda, T</creatorcontrib><creatorcontrib>Kitajima, M</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Yamashita, Y</creatorcontrib><title>Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.</description><subject>Adult Brain</subject><subject>Aged</subject><subject>Editor's Choice</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Iron - analysis</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>ROC Curve</subject><subject>Substantia Nigra - chemistry</subject><subject>Substantia Nigra - diagnostic imaging</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1v1DAQtRCILoULPwD5iJBSHCex4wvSqoVSacuHChI3y47Huy6Jk9pOq_1H_EwctlRwGc943nvj8UPoZUlOqpLXb9W1DyfrmtXNI7QqRcUK0Ygfj9GKlKIpWEnaI_QsxmtCSCM4fYqOKGsp5bRdoV8blSCoHq_jfhgghT1W3uCrSSWXb8-ctRDAd4BHiy_C6PEZTGN0yeXUeZx2gK9mHZPymYA_uW1QC_RL5oNPEd-5tMtV-Ol8XNgugoqAL3OcA5hD_-u80FPm3C5ysYMpOe16l_b4Uk2T89vn6IlVfYQX9-cx-v7h_bfTj8Xm8_nF6XpTdHUpUsEsbTpiCOcdoaYGS0ETME2tGKssp402baOsaTUxLe-UFZyAILwVptS11tUxenfQnWY9gOnyEvl75BTcoMJejsrJ_zve7eR2vJV1yzhlPAu8vhcI480MMcnB5YX6XnkY5yjLPItUoqpJhr45QLswxhjAPowpiVyslYu18o-1Gfzq34c9QP96Wf0GSW6l6Q</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Azuma, M</creator><creator>Hirai, T</creator><creator>Yamada, K</creator><creator>Yamashita, S</creator><creator>Ando, Y</creator><creator>Tateishi, M</creator><creator>Iryo, Y</creator><creator>Yoneda, T</creator><creator>Kitajima, M</creator><creator>Wang, Y</creator><creator>Yamashita, Y</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1480-2197</orcidid><orcidid>https://orcid.org/0000-0001-7115-9105</orcidid><orcidid>https://orcid.org/0000-0002-9586-8341</orcidid><orcidid>https://orcid.org/0000-0003-1404-8526</orcidid><orcidid>https://orcid.org/0000-0002-2905-1093</orcidid><orcidid>https://orcid.org/0000-0002-4837-4197</orcidid><orcidid>https://orcid.org/0000-0001-0311-5466</orcidid><orcidid>https://orcid.org/0000-0001-9315-3492</orcidid><orcidid>https://orcid.org/0000-0001-9488-8781</orcidid><orcidid>https://orcid.org/0000-0002-6869-3638</orcidid><orcidid>https://orcid.org/0000-0002-7941-637X</orcidid></search><sort><creationdate>201605</creationdate><title>Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping</title><author>Azuma, M ; Hirai, T ; Yamada, K ; Yamashita, S ; Ando, Y ; Tateishi, M ; Iryo, Y ; Yoneda, T ; Kitajima, M ; Wang, Y ; Yamashita, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-6f25c0d077c02d4ef2eb0ed54a663f725bd85afd8b0d87caf970e90789d1b4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult Brain</topic><topic>Aged</topic><topic>Editor's Choice</topic><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Iron - analysis</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>ROC Curve</topic><topic>Substantia Nigra - chemistry</topic><topic>Substantia Nigra - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azuma, M</creatorcontrib><creatorcontrib>Hirai, T</creatorcontrib><creatorcontrib>Yamada, K</creatorcontrib><creatorcontrib>Yamashita, S</creatorcontrib><creatorcontrib>Ando, Y</creatorcontrib><creatorcontrib>Tateishi, M</creatorcontrib><creatorcontrib>Iryo, Y</creatorcontrib><creatorcontrib>Yoneda, T</creatorcontrib><creatorcontrib>Kitajima, M</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Yamashita, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azuma, M</au><au>Hirai, T</au><au>Yamada, K</au><au>Yamashita, S</au><au>Ando, Y</au><au>Tateishi, M</au><au>Iryo, Y</au><au>Yoneda, T</au><au>Kitajima, M</au><au>Wang, Y</au><au>Yamashita, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>37</volume><issue>5</issue><spage>782</spage><epage>788</epage><pages>782-788</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>26822728</pmid><doi>10.3174/ajnr.A4645</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1480-2197</orcidid><orcidid>https://orcid.org/0000-0001-7115-9105</orcidid><orcidid>https://orcid.org/0000-0002-9586-8341</orcidid><orcidid>https://orcid.org/0000-0003-1404-8526</orcidid><orcidid>https://orcid.org/0000-0002-2905-1093</orcidid><orcidid>https://orcid.org/0000-0002-4837-4197</orcidid><orcidid>https://orcid.org/0000-0001-0311-5466</orcidid><orcidid>https://orcid.org/0000-0001-9315-3492</orcidid><orcidid>https://orcid.org/0000-0001-9488-8781</orcidid><orcidid>https://orcid.org/0000-0002-6869-3638</orcidid><orcidid>https://orcid.org/0000-0002-7941-637X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-6108 |
| ispartof | American journal of neuroradiology : AJNR, 2016-05, Vol.37 (5), p.782-788 |
| issn | 0195-6108 1936-959X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4867267 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Brain Aged Editor's Choice Female Gray Matter - diagnostic imaging Humans Imaging, Three-Dimensional - methods Iron - analysis Magnetic Resonance Imaging - methods Male Middle Aged Parkinson Disease - diagnostic imaging ROC Curve Substantia Nigra - chemistry Substantia Nigra - diagnostic imaging |
| title | Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T21%3A10%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lateral%20Asymmetry%20and%20Spatial%20Difference%20of%20Iron%20Deposition%20in%20the%20Substantia%20Nigra%20of%20Patients%20with%20Parkinson%20Disease%20Measured%20with%20Quantitative%20Susceptibility%20Mapping&rft.jtitle=American%20journal%20of%20neuroradiology%20:%20AJNR&rft.au=Azuma,%20M&rft.date=2016-05&rft.volume=37&rft.issue=5&rft.spage=782&rft.epage=788&rft.pages=782-788&rft.issn=0195-6108&rft.eissn=1936-959X&rft_id=info:doi/10.3174/ajnr.A4645&rft_dat=%3Cproquest_pubme%3E1789039340%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1789039340&rft_id=info:pmid/26822728&rfr_iscdi=true |