NADPH oxidase is implicated in the pathogenesis of oxidative phosphorylation dysfunction in mice fed a high-fat diet

The aim of this study was to evaluate the role of NADPH oxidase (NADPHox) in the pathogenesis of oxidative phosphorylation (OXPHOS) dysfunction as found in mice fed a high-fat diet (HFD). C57BL/6J mice were distributed in four groups: WT/SCD: six wild-type (WT) mice fed a standard chow diet (SCD); W...

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Veröffentlicht in:	Scientific reports 2016-05, Vol.6 (1), p.23664-23664, Article 23664
Hauptverfasser:	García-Ruiz, Inmaculada, Solís-Muñoz, Pablo, Fernández-Moreira, Daniel, Grau, Montserrat, Muñoz-Yagüe, Teresa, Solís-Herruzo, José A.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/29 64/60 692/4020/4021 692/4020/4021/1607 692/4020/4021/1607/2751 8-Hydroxy-2'-Deoxyguanosine 82/29 82/51 82/80 Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Diet, High-Fat Disease Models, Animal DNA Damage ERRalpha Estrogen-Related Receptor Gene Expression Humanities and Social Sciences Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism multidisciplinary NADPH Oxidase 2 - deficiency NADPH Oxidase 2 - genetics NADPH Oxidase 2 - metabolism Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Oxidative Phosphorylation Oxidative Stress Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Science
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