Interferon-gamma-dependent Immunity in Bacillus Calmette-Guérin Vaccine Osteitis Survivors

BACKGROUND:Inborn errors of interferon-gamma (IFN-γ)-mediated immunity underlie disseminated disease caused by Mycobacterium bovis Bacillus Calmette-Guérin (BCG) live vaccines. We hypothesized that some patients with osteitis after BCG vaccination may have an impaired IFN-γ immunity. Our aim was to...

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Veröffentlicht in:	The Pediatric infectious disease journal 2016-06, Vol.35 (6), p.690-694
Hauptverfasser:	Pöyhönen, Laura, Kröger, Liisa, Huhtala, Heini, Mäkinen, Johanna, Mertsola, Jussi, Martinez-Barricarte, Ruben, Casanova, Jean-Laurent, Bustamante, Jacinta, He, Qiushui, Korppi, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BCG Vaccine - administration & dosage BCG Vaccine - adverse effects Female Finland Humans Immunologic Factors - genetics Interferon-gamma - metabolism Interleukin-12 - metabolism Leukocytes, Mononuclear - immunology Male Middle Aged Mycobacterium bovis - immunology Osteitis - chemically induced Osteitis - immunology Survivors Young Adult
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