FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions

In hypoxic cells, dysfunctional mitochondria are selectively removed by a specialized autophagic process called mitophagy. The ER–mitochondrial contact site (MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 interacts with LC3 to r...

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Veröffentlicht in:	The EMBO journal 2016-07, Vol.35 (13), p.1368-1384
Hauptverfasser:	Wu, Wenxian, Lin, Chunxia, Wu, Keng, Jiang, Lei, Wang, Xiaojing, Li, Wen, Zhuang, Haixia, Zhang, Xingliang, Chen, Hao, Li, Shupeng, Yang, Yue, Lu, Yue, Wang, Jingjing, Zhu, Runzhi, Zhang, Liangqing, Sui, Senfang, Tan, Ning, Zhao, Bin, Zhang, Jingjing, Li, Longxuan, Feng, Du
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagy Calnexin - metabolism Cells, Cultured Cellular biology Dynamins EMBO07 EMBO20 EMBO21 Endoplasmic Reticulum - metabolism ER-mitochondrial contact site GTP Phosphohydrolases - metabolism Humans Hypoxia MAM Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Mitochondria Mitochondrial Dynamics mitochondrial fission Mitochondrial Proteins - metabolism Mitophagy Protein Binding Proteins
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