Superoxide mediates tight junction complex dissociation in cyclically stretched lung slices

Abstract We found that stretching Type I rat alveolar epithelial cell (RAEC) monolayers at magnitudes that correspond to high tidal-volume mechanical ventilation results in the production of reactive oxygen species, including nitric oxide and superoxide. Scavenging superoxide with Tiron eliminated t...

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Veröffentlicht in:	Journal of biomechanics 2016-05, Vol.49 (8), p.1330-1335
Hauptverfasser:	Song, Min Jae, Davidovich, Nurit, Lawrence, Gladys G, Margulies, Susan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Controllers Epithelial Cells - metabolism Epithelial Cells - physiology In Vitro Techniques Injuries Lung injury Lungs Monolayers Mortality Nitric Oxide - metabolism Oxidative Stress Permeability Physical Medicine and Rehabilitation Programmable logic devices Proteins Pulmonary Alveoli - cytology Pulmonary Alveoli - physiology Rats Rats, Sprague-Dawley Respiratory distress syndrome Scavenging Studies Superoxides - metabolism Tight junctions Tight Junctions - physiology Ventilation Ventilator-Induced Lung Injury - metabolism Ventilator-Induced Lung Injury - physiopathology Ventilators
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