How May Proton Pump Inhibitors Impair Cardiovascular Health?

Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an...

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Veröffentlicht in:	American journal of cardiovascular drugs : drugs, devices, and other interventions devices, and other interventions, 2016-06, Vol.16 (3), p.153-161
Hauptverfasser:	Sukhovershin, Roman A., Cooke, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - adverse effects Cardiology Cardiovascular Diseases - chemically induced Cardiovascular Diseases - epidemiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Cardiovascular System - drug effects Cardiovascular System - metabolism Cardiovascular System - physiopathology Current Opinion Drug Monitoring Evidence-Based Medicine Humans Medicine Medicine & Public Health Models, Cardiovascular Nonprescription Drugs - adverse effects Pharmacology/Toxicology Pharmacotherapy Practice Guidelines as Topic Proton Pump Inhibitors - adverse effects Risk Factors
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Beschreibung
Zusammenfassung:	Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.
ISSN:	1175-3277 1179-187X
DOI:	10.1007/s40256-016-0160-9