The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway

Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme involved in tumor malignancy. However, the regulatory mechanism underlying its involvement remains largely uncharacterized. The present study aimed to investigate the hypothesis that NK4, an antagonist of hepatocyte growth factor (HGF)...

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Veröffentlicht in:	International journal of oncology 2016-06, Vol.48 (6), p.2303-2309
Hauptverfasser:	WANG, DONGDONG, SAGA, YASUSHI, SATO, NAOTO, NAKAMURA, TOSHIKAZU, TAKIKAWA, OSAMU, MIZUKAMI, HIROAKI, MATSUBARA, SHIGEKI, FUJIWARA, HIROYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Butadienes - pharmacology Carcinogenesis Cell growth Cell Line, Tumor Cellular signal transduction Chromones - pharmacology Female Genetic aspects Growth factors Health aspects hepatocyte growth factor Hepatocyte Growth Factor - biosynthesis Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Heterografts Humans Hypotheses Immunoglobulins indoleamine-2,3-dioxygenase Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis Indoles - pharmacology Killer cells Kinases Mice Mice, Inbred BALB C Mice, Nude Morpholines - pharmacology Nitriles - pharmacology NK4 Ovarian cancer Ovarian Neoplasms - enzymology Ovarian Neoplasms - metabolism Oxidoreductases Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Properties Proteins Proto-Oncogene Proteins c-met - metabolism PTEN PTEN Phosphohydrolase Pyridines - pharmacology Signal Transduction - drug effects Studies Sulfones - pharmacology Tumors Tyrphostins - pharmacology
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