Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis

Management of bone metastasis remains clinically challenging and requires the identification of new molecular target(s) that can be therapeutically exploited to improve patient outcome. Galectin-3 (Gal-3) has been implicated as a secreted factor that alters the bone microenvironment. Proteolytic cle...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-03, Vol.76 (6), p.1391-1402
Hauptverfasser:	Nakajima, Kosei, Kho, Dhong Hyo, Yanagawa, Takashi, Harazono, Yosuke, Hogan, Victor, Chen, Wei, Ali-Fehmi, Rouba, Mehra, Rohit, Raz, Avraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Animals Bone and Bones - metabolism Bone and Bones - pathology Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Bone Remodeling - physiology Breast - metabolism Breast - pathology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Communication - physiology Cell Differentiation - physiology Cell Line, Tumor Female Galectin 3 - metabolism Humans Isoenzymes - metabolism Male Mice Myosins - metabolism Neoplasm Metastasis - pathology Osteoclasts - metabolism Osteoclasts - pathology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RANK Ligand - metabolism Tartrate-Resistant Acid Phosphatase
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