Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction

Oxidative stress is a distinctive sign in several genetic disorders characterized by cancer predisposition, such as Ataxia-Telangiectasia, Fanconi Anemia, Down syndrome, progeroid syndromes, Beckwith-Wiedemann syndrome, and Costello syndrome. Recent literature unveiled new molecular mechanisms linki...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-7
Hauptverfasser:	Longini, M., Guidoni, Elisa, Geronzi, Ursula, Lotti, Federica, Perrone, Serafina, Buonocore, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aging Animals Anticarcinogenic Agents - therapeutic use Antioxidants Antioxidants - therapeutic use Apoptosis Beckwith-Wiedemann Syndrome - complications Beckwith-Wiedemann Syndrome - drug therapy Beckwith-Wiedemann Syndrome - genetics Beckwith-Wiedemann Syndrome - metabolism Bioenergetics Biomarkers Cancer Cell cycle Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Children Clinical trials Deoxyribonucleic acid Diseases DNA DNA damage DNA methylation Down syndrome Fanconi's anemia Free radicals Gene expression Genetic aspects Genetic disorders Genetic Predisposition to Disease Health aspects Humans Injuries Ionizing radiation Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Diseases - drug therapy Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Mitochondrial DNA Neoplasms - genetics Neoplasms - metabolism Neoplasms - prevention & control Oxidative stress Oxidative Stress - drug effects Pathogenesis Patients Pediatrics Physiology Potassium Prader-Willi Syndrome - complications Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - genetics Prader-Willi Syndrome - metabolism Proteins Risk Factors Type 2 diabetes Vitamin C
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