Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

Streptococcus pneumoniae (the pneumococcus) is capable of invading the heart. Herein we observed that pneumococcal invasion of the myocardium occurred soon after development of bacteremia and was continuous thereafter. Using immunofluorescence microscopy (IFM), we observed that S. pneumoniae replica...

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Veröffentlicht in:	Infection and immunity 2016-05, Vol.84 (5), p.1457-1469
Hauptverfasser:	Gilley, Ryan P, González-Juarbe, Norberto, Shenoy, Anukul T, Reyes, Luis F, Dube, Peter H, Restrepo, Marcos I, Orihuela, Carlos J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteremia - pathology Bacterial Infections Bacterial Proteins - metabolism Bacterial Proteins - toxicity Cell Death - drug effects Cell Line Disease Models, Animal Female Humans Macrophages - drug effects Macrophages - physiology Mice, Inbred BALB C Microscopy, Fluorescence Myocarditis - pathology Pneumococcal Infections - pathology Protein Kinases - analysis Spotlight Streptococcus pneumoniae Streptococcus pneumoniae - metabolism Streptococcus pneumoniae - pathogenicity Streptolysins - metabolism Streptolysins - toxicity
Online-Zugang:	Volltext
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